Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas
| Autor: | A. F. Vozianov, A. V. Gerashchenko, Eugene R. Zabarovsky, V. V. Gordiyuk, Y. M. Zgonnyk, L. A. Stoliar, Vladimir I. Kashuba, Alla Rynditch, S. M. Kvasha, A. G. Kondratov |
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| Rok vydání: | 2011 |
| Předmět: |
Cancer Research
Tumor suppressor gene Biology medicine.disease_cause Biochemistry Genetics medicine Humans Promoter Regions Genetic Carcinoma Renal Cell Molecular Biology Neoplasm Staging Promoter Methylation DNA Methylation medicine.disease Molecular biology Kidney Neoplasms Neoplasm Proteins Clear cell renal cell carcinoma Oncology DNA methylation Cancer research Molecular Medicine Carcinogenesis A431 cells Clear cell |
| Zdroj: | Molecular Medicine Reports. |
| ISSN: | 1791-3004 1791-2997 |
| Popis: | The leucine rich repeat containing 3B (LRRC3B) gene is a putative tumor suppressor located on human chromosome 3 in the 3p24 region. LRRC3B is frequently altered in colon and gastric cancers and also in leukaemias. In this study we investigated the promoter region methylation as a possible mechanism of LRRC3B gene inactivation in clear cell renal cell carcinomas. We found that the LRRC3B gene promoter was methylated in 43% of clear cell renal carcinoma samples. However, no correlation between DNA methylation and LRRC3B expression was found. |
| Databáze: | OpenAIRE |
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