Amelioration of hyperglycemia by Rubus occidentalis (black raspberry) and increase in short-chain fatty acids producing bacteria
| Autor: | Kyungjae Kim, Su Jung Lee, Youngcheon Song, Kyu Seo Chae, Hye Ran Choi, Jiyeon Kim, Jinho An, Heetae Lee, Ji Wung Kwon, Hyunseok Kong, Sungwon Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Medicine (miscellaneous) Gut microbiota Gut flora 03 medical and health sciences Short-chain fatty acids 0404 agricultural biotechnology Insulin resistance Black raspberry medicine TX341-641 Food science Glucose tolerance test 030109 nutrition & dietetics Nutrition and Dietetics medicine.diagnostic_test biology Nutrition. Foods and food supply Ruminococcus 04 agricultural and veterinary sciences biology.organism_classification medicine.disease 040401 food science Rubus occidentalis (RO) Hyperglycemia Bacteroides Rubus Bacteria Food Science |
| Zdroj: | Journal of Functional Foods, Vol 54, Iss, Pp 433-439 (2019) |
| ISSN: | 1756-4646 |
| Popis: | Increasing evidence suggests that gut microbiota play an important role in metabolic disorders. Rubus occidentalis (RO) (black raspberry) has antioxidant and anti-inflammatory effects and improves metabolic disorders such as hypertension and insulin resistance. This study investigated the composition of gut microbiota in RO-treated mice using an aged mouse model of high-fat diet-induced obesity. RO significantly improved mouse glucose profiles, including serum glucose levels and intraperitoneal glucose tolerance test results. RO treatment caused significant increases in the relative abundance of various genera including Bacteroides, Butyricimonas, Mucispirillum, and Ruminococcus. Moreover, these increased genera correlated with the glucose profiles. Our findings suggest that the effect of RO on glucose control is associated with an increase in short-chain fatty acids producing bacteria. |
| Databáze: | OpenAIRE |
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