Increasing incidence of childhood tumours of the central nervous system in Denmark, 1980–1996
| Autor: | Raaschou-Nielsen, Ole Lundsgaard, Sørensen, M, Carstensen, H, Jensen, T, Bernhardtsen, T, Gjerris, F, Schmiegelow, K, Jensen, Thomas Hartvig Lindkjær |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Cancer Research
Pediatrics medicine.medical_specialty Adolescent Databases Factual Epidemiology Denmark Population neoplasms Sensitivity and Specificity Time Central Nervous System Neoplasms Humans Medicine Registries Child education Survival rate child education.field_of_study business.industry Incidence Incidence (epidemiology) Medical record Mortality rate Infant Newborn Infant central nervous system mortality Magnetic Resonance Imaging Confidence interval Survival Rate Oncology El Niño Child Preschool Population Surveillance Tomography X-Ray Computed business |
| Zdroj: | Raaschou-Nielsen, O L, Sørensen, M, Carstensen, H, Jensen, T, Bernhardtsen, T, Gjerris, F, Schmiegelow, K & Jensen, T H L 2006, ' Increasing incidence of childhood tumours of the central nervous system in Denmark, 1980-1996 ' B J C, vol. 95, no. 3, pp. 416-22 . https://doi.org/10.1038/sj.bjc.6603278 British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | The registered incidence rate of childhood central nervous system (CNS) tumours has increased in several countries. It is uncertain whether these increases are biologically real or owing to improved diagnostic methods. We explored the medical records of 626 CNS tumours diagnosed in Danish children between 1980 and 1996. Population-based registers were used to extract data on mortality and background population. Temporal patterns were analysed by regression techniques. Most tumours were verified by computed tomography (78%) or magnetic resonance imaging (14%). Overall, the incidence rate increased by 2.9% per year (95% confidence interval (CI): 1.3;4.5) and the mortality rate increased by 1.4% per year (95% CI: −0.4;3.3). Among children aged 0–4 years, the survival rate after diagnosis remained almost unchanged, whereas among children aged 5–14 years, the 10-year survival rate improved from 59 to 74%. These data suggest that the incidence rate of CNS tumours among Danish children has truly increased, although alternative explanations cannot be excluded. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|