Toll-like Receptor 2 and Toll-like Receptor 4 Expression in Human Adrenals
| Autor: | R. R. Schumann, V. Rettori, Kai Zacharowski, S. M. McCann, Stefan R. Bornstein |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Clinical Biochemistry Receptors Cell Surface Inflammation Biology Biochemistry Sepsis Endocrinology Internal medicine medicine Humans Toll-like receptor Membrane Glycoproteins Innate immune system Adrenal cortex Toll-Like Receptors Biochemistry (medical) General Medicine medicine.disease Immunohistochemistry Toll-Like Receptor 2 Toll-Like Receptor 4 TLR2 medicine.anatomical_structure Adrenal Medulla Immunology Adrenal Cortex TLR4 medicine.symptom Adrenal medulla |
| Zdroj: | Hormone and Metabolic Research. 36:470-473 |
| ISSN: | 1439-4286 0018-5043 |
| DOI: | 10.1055/s-2004-825750 |
| Popis: | Toll-like receptors (TLRs) are key elements in the innate immune response, functioning as pattern-recognition receptors for the detection and response to endotoxins and other microbial ligands. Inflammatory cytokines play an important role in the activation of the hypothalamic-pituitary-adrenal HPA axis during inflammation and sepsis. The newly recognized major role of TLR2 and TLR4 and the adrenal stress response during critical illnesses such as inflammation and sepsis demand comprehensive analysis of their interactions. Therefore, we analyzed TLR2 and TLR4 expression in human adrenal glands. Western blot analysis demonstrated the expression of TLR2 and TLR4 in the human adrenocortical cell line NCI-H295. Immunohistochemical analysis of normal human adrenal glands revealed TLR2 and TLR4 expression in the adrenal cortex, but not in the adrenal medulla. Considering the crucial role of the HPA axis and the innate immune response during acute sepsis or septic shock, elucidating the functional interaction of these systems should be of great clinical relevance. |
| Databáze: | OpenAIRE |
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