| Autor: |
Christine Stier, Ann-Cathrin Koschker, Mia Kim, Raphael Stier, Sonja Chiappetta, Jürgen Stein |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Clinical Nutrition ESPEN. 50:238-246 |
| ISSN: |
2405-4577 |
| Popis: |
Severe obesity (BMI ≥60 kg/mIn this proof-of-concept study, prospective data from patients treated with RWR (intervention group 1, n = 26) were mathematically matched with retrospective biometric data of 26 patients with severe obesity (historic control group 2) who underwent standard 6-month bridging with IB. A rating scale was developed to identify patients needing urgent fast-track bridging.Rapid weight loss was observed in all patients on the RWR therapy. All achieved operability after a mean RWR bridging duration of 20.7 ± 6.9 days. Baseline weight was 236.3 ± 35.8 kg in group 1 compared with 230.1 ± 32.7 kg in group 2. Mean body weight loss during RWR was 27.5 ± 14.1 kg, compared with 20.9 ± 10.5 kg in group 2 (P = 0.0629).Pre-operative bridging using liraglutide in combination with a leucine-rich amino acid infusion and hypocaloric diet was effective in all cases of acutely life-threatening severe obesity, achieving technical operability within only ca. 2-4 weeks. This therapy has potential as a life-saving rescue therapy for multimorbid patients with severe obesity who were previously untreatable. This study is registered at ClinicalTrials.gov (identifier: NCT02616003). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect