Comparison of uptake between PureSorb-Q40 and regular hydrophobic coenzyme Q10 in rats and humans after single oral intake
| Autor: | Toshihiko Yamagishi, Kazuki Nukui, Hiromi Miyawaki, Aikkarach Kettawan, Kiyoshi Sato, Tadashi Okamoto |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Antioxidant Time Factors Ubiquinone medicine.medical_treatment Coenzymes Medicine (miscellaneous) Administration Oral Capsules Absorption (skin) Raw material Dosage form Antioxidants Rats Sprague-Dawley chemistry.chemical_compound Random Allocation Functional food Oral administration Reference Values medicine Animals Humans Food science Chromatography High Pressure Liquid Coenzyme Q10 Nutrition and Dietetics Cross-Over Studies Vitamins Crossover study Rats chemistry Biochemistry Food Hydrophobic and Hydrophilic Interactions Tablets |
| Zdroj: | Journal of nutritional science and vitaminology. 53(2) |
| ISSN: | 0301-4800 |
| Popis: | Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant and essential component of the mitochondrial electron transfer system in the body, and is in wide use as a functional food material and cosmetic raw material. However, as CoQ10 is extremely lipid-soluble, absorption by the body is not easy. In general, people use soft-gel capsules in which CoQ10 is suspended in oil, and take these capsules with food. PureSorb-Q40 (P40) was developed to improve CoQ10 processability and absorption when taken without food, and the present study compared the effects of food on absorption between P40 and conventional lipid-soluble CoQ10 in rats and humans. The results of a rat study showed higher uptake when P40 was administered in the fasting state or with food compared to lipid-soluble CoQ10. The results of a human study showed that uptake was favorable when P40 was administered in the fasting state, and even when administered postprandially, a significant difference was noted in uptake rate up to 6 h after intake and uptake volume up to 8 h after intake when compared to lipid-soluble CoQ10. These results show that any CoQ10 product using P40 can be quickly and reliably absorbed by the body regardless of dosage form or intake time. |
| Databáze: | OpenAIRE |
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