Progressive dysregulation of autonomic and HPA axis functions in HIV-1 clade C infection in South India

Autor: H. Ravi Kumar, K.S. Satish, K. Taranath Shetty, R.S. Bhimasena Rao, Mahendra Kumar, Mariyamma Philip, Seetharamaiah Chittiprol, Parthasarthy Satishchandra, D.K. Subbakrishna, Adarsh M. Kumar
Rok vydání: 2008
Předmět:
Adult
Male
Hypothalamo-Hypophyseal System
medicine.medical_specialty
Adolescent
Epinephrine
Hydrocortisone
medicine.drug_class
Endocrinology
Diabetes and Metabolism
India
Pituitary-Adrenal System
Adrenocorticotropic hormone
Biology
Autonomic Nervous System
Asymptomatic
Statistics
Nonparametric
Norepinephrine
Basal (phylogenetics)
Endocrinology
Adrenocorticotropic Hormone
Reference Values
HIV Seronegativity
Internal medicine
HIV Seropositivity
medicine
Humans
Longitudinal Studies
Biological Psychiatry
Analysis of Variance
Endocrine and Autonomic Systems
Area under the curve
Middle Aged
Adaptation
Physiological
Neurosecretory Systems
Psychiatry and Mental health
Autonomic nervous system
Motor Skills
Area Under Curve
Case-Control Studies
HIV-1
Corticosteroid
Female
medicine.symptom
Stress
Psychological
Glucocorticoid
medicine.drug
Zdroj: Psychoneuroendocrinology. 33:30-40
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2007.09.006
Popis: Human immunodeficiency virus type 1 (HIV-1) infection causes a wide spectrum of abnormalities in neurological, neuropsychological, and neuroendocrinological functions. Several studies report disturbance in autonomic nervous system (ANS) and hypothalamic pituitary-adrenal (HPA) axis function in HIV-1B infected individuals. However, no such investigations on the effect of HIV-1 clade C infection, particularly during the initial phase of the disease progression, have been reported. The present investigations were carried out longitudinally over a 2-year period at 12 monthly intervals in clinically asymptomatic HIV-1 clade C seropositive patients (n=120) and seronegative control subjects (n=29). We determined both the basal levels and the dynamic changes in plasma levels of norepinephrine (NE), epinephrine (E), adrenocorticotrophic hormone (ACTH) and cortisol (CORT). Studies were also extended longitudinally (at three separate yearly visits of each participant), to evaluate the response of autonomic and HPA axis to mirror star tracing challenge test (MSTCT) and the values were determined as area under the curve (AUC, corrected for baseline levels of NE, E, ACTH, and CORT). The findings show that the values of basal plasma NE levels, as well as NE response to MSTCT (AUC) at the first visit of HIV-1 seropositive individuals did not differ from those found in the control subjects (NE, pg/ml, HIV-1C=313.5+/-12.7 vs. controls=353.0+/-21.3; p=NS; AUC, HIV-1C=225+/-14.75 vs. controls=232.7+/-19.34; p=NS, respectively). At the subsequent two visits of HIV-1 positive patients however, NE response to MSTCT challenge was progressively attenuated (AUC=235+/-19.5 and 162.7+/-13.6; p
Databáze: OpenAIRE
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