Mathematical modeling of drug delivery from torus-shaped single-layer devices
| Autor: | Julio Alberto Luna, Maria Ines Cabrera, Ignacio Marcelo Helbling |
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| Rok vydání: | 2011 |
| Předmět: |
Materials science
Contraceptive Devices Female Pharmaceutical Science Experimental data Torus Mechanics Controlled release Diffusion Drug Delivery Systems Reliability (semiconductor) Models Chemical Pharmaceutical Preparations Drug delivery Humans Computer Simulation Female Solubility Diffusion (business) Drug carrier |
| Zdroj: | Journal of Controlled Release. 149:258-263 |
| ISSN: | 0168-3659 |
| Popis: | A mathematical modeling of controlled release of drug from torus-shaped single-layer devices is presented. Analytical solutions based on the pseudo-steady state approximation are derived. The reliability and usefulness of the model are ascertained by comparison of the simulation results with matrix-type vaginal ring experimental release data reported in the literature. A good agreement between the model prediction and the experimental data is observed. An analysis of the effect of the variation in torus design parameters on the solute release is also presented. The model is applicable only to torus-shaped single-layer systems wherein the initial load of drug is higher than its solubility in the polymer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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