Lupus Podocytopathy: An Overview
| Autor: | Elena Oliva-Damaso, Andrew S. Bomback, Nestor Oliva-Damaso, Juan Payan, Teresa Pereda |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty Nephrotic Syndrome Kidney Glomerulus 030232 urology & nephrology Lupus nephritis 030204 cardiovascular system & hematology Article 03 medical and health sciences 0302 clinical medicine Focal segmental glomerulosclerosis immune system diseases medicine Humans Lupus Erythematosus Systemic Minimal change disease skin and connective tissue diseases Proteinuria Systemic lupus erythematosus Podocytes business.industry Primary Focal Segmental Glomerulosclerosis Disease Management medicine.disease Lupus Nephritis Nephrology Mesangial proliferative glomerulonephritis medicine.symptom business Nephrotic syndrome |
| Zdroj: | Adv Chronic Kidney Dis |
| ISSN: | 1548-5595 |
| DOI: | 10.1053/j.ackd.2019.08.011 |
| Popis: | In systemic lupus erythematosus, nephrotic-range proteinuria typically signals the presence of a proliferative lupus nephritis (class III/IV) and/or membranous lupus nephritis (class V, with or without concomitant class III or IV lesions). However, in rare instances, systemic lupus erythematosus patients with nephrotic syndrome have kidney biopsy findings of normal glomeruli or focal segmental glomerulosclerosis lesions, with or without mesangial proliferation, on light microscopy; the absence of subepithelial or subendothelial deposits on immunofluorescence and electron microscopy; and diffuse foot process effacement on electron microscopy. This pattern, termed lupus podocytopathy, is a unique form of lupus nephritis that mimics minimal change disease or primary focal segmental glomerulosclerosis and represents approximately 1% of lupus nephritis biopsies. Here we review the clinical features, histological manifestations, diagnostic criteria and classification, pathogenesis, treatment, and prognosis of lupus podocytopathy. |
| Databáze: | OpenAIRE |
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