Keratoconus in Inflammatory Bowel Disease Patients: A Cross-sectional Study
| Autor: | Karine Angioi, Guillaume Conroy, Mathilde Portier, Véronique Cloché, Clothilde Latarche, Laurent Peyrin-Biroulet, Benjamine Batta, F Trechot, Charlotte Andrianjafy, Pauline Beaujeux, J.-B. Conart |
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| Přispěvatelé: | Service d'ophtalmologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL) |
| Rok vydání: | 2015 |
| Předmět: |
Male
genetic structures [SDV]Life Sciences [q-bio] medicine.medical_treatment Inflammatory bowel disease 0302 clinical medicine Risk Factors Refractive surgery Prevalence Prospective Studies Family history Prospective cohort study corneal topography Disorders medicine.diagnostic_test Gastroenterology General Medicine Middle Aged Corneal topography Ulcerative colitis 3. Good health Female France Adult medicine.medical_specialty Keratoconus 03 medical and health sciences inflammatory bowel disease Internal medicine medicine Humans Crohns-Disease Risk factor Aged business.industry Videokeratography Molecules Inflammatory Bowel Diseases medicine.disease digestive system diseases eye diseases Surgery Cross-Sectional Studies Case-Control Studies Tears 030221 ophthalmology & optometry sense organs business 030215 immunology |
| Zdroj: | Journal of Crohn's and Colitis Journal of Crohn's and Colitis, Elsevier-Oxford University Press, 2015, 9 (12), pp.1108-1112. ⟨10.1093/ecco-jcc/jjv151⟩ |
| ISSN: | 1876-4479 1873-9946 |
| DOI: | 10.1093/ecco-jcc/jjv151 |
| Popis: | International audience; Background and Aims: Increasing evidence suggests that keratoconus may have an inflammatory component. The possible association of keratoconus with inflammatory bowel disease (IBD) has yet to be determined. The aim of this study was to determine the prevalence of keratoconus and suspect keratoconus in patients with IBD.Methods: All consecutive adult IBD patients seen in the Department of Gastroenterology, Nancy, University Hospital, France, between March 2014 and June 2014 were included. Pregnant women, rigid lens wearers, patients with a family history of keratoconus and patients with a history of refractive surgery were excluded. A control group of healthy subjects was included. All included patients underwent a corneal topography (OPD-Scan III, Nidek) to detect keratoconus or suspect keratoconus. Rabinowitz videokeratographic indices were the basis of corneal topography interpretation.Results: Two hundred and one IBD patients were included, 150 with Crohn's disease and 51 with ulcerative colitis. Mean age was 38.7 years and 121 were women. Mean disease duration was 10.8 years. Two IBD patients were diagnosed with keratoconus (1%) and 38 with suspect keratoconus (18.9%). Overall prevalence of keratoconus and suspect keratoconus was 19.9% (95% confidence interval [CI] 17.5-22.0). None of the 100 healthy subjects had keratoconus, while three were diagnosed with suspect keratoconus (p = 0.0002 versus IBD patients). Only smoking was identified as a risk factor (p = 0.029), especially in Crohn's disease.Conclusion: Inflammatory bowel disease patients may carry an increased risk of keratoconus and suspect keratoconus, smoking further increasing this risk. This supports the hypothesis of an inflammatory origin of keratoconus. |
| Databáze: | OpenAIRE |
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