Ethnicity and response to primary three-dose hepatitis B vaccination in employees in the Netherlands, 1983 through 2017
| Autor: | Cécile Kremer, Ger H. Koek, Özgür M Koc, Niel Hens, Astrid M. L. Oude Lashof, Charlotte Menart, Jemimah Theodore |
|---|---|
| Přispěvatelé: | Faculteit FHML Centraal, RS: NUTRIM - R2 - Liver and digestive health, Med Microbiol, Infect Dis & Infect Prev, Interne Geneeskunde, MUMC+: MA Maag Darm Lever (9), MUMC+: DA MMI Staf (9), RS: CAPHRI - R4 - Health Inequities and Societal Participation |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male SURFACE-ANTIGEN Vaccination schedule ANTIBODY-RESPONSE UNITED-STATES INFANTS VIRUS-INFECTION medicine.disease_cause Logistic regression determinant IMMUNOGENICITY 03 medical and health sciences 0302 clinical medicine nonresponse Virology medicine Humans IMMUNE-RESPONSE Hepatitis B Vaccines 030212 general & internal medicine Hepatitis B Antibodies Immunization Schedule Netherlands Retrospective Studies Hepatitis B virus business.industry healthcare workers Vaccination Odds ratio Hepatitis B medicine.disease IMMUNIZATION PREVALENCE Logistic Models Infectious Diseases Immunization Population study ethnicity Female 030211 gastroenterology & hepatology Human medicine hepatitis B HEALTH-CARE WORKERS business Demography |
| Zdroj: | Journal of Medical Virology, 92(3), 309-316. Wiley Journal of medical virology |
| ISSN: | 0146-6615 |
| Popis: | Background and Aims Hepatitis B virus (HBV) vaccination is recommended to all employees who have an occupational risk in the Netherlands. This study assessed the determinants of the immune response to primary standard three-dose HBV vaccination (0, 1, 6 months), with the main focus on ethnicity. Methods Out of 76 239 individuals who received HBV vaccination between April 1983 and December 2017, 11 567 persons with a known country of birth and complete vaccination schedule were included in this study. Weighted multiple logistic regression with Firth's bias adjustment was used to assess the determinants of nonresponse (anti-HBs < 10 mIU/mL) and low response (anti-HBs 10-99 mIU/mL). Results Baseline characteristics of the study population (n = 11 567) were as follows: mean age 27.5 years (95% confidence interval [CI], 27.23-27.72), 99.4% born in the Netherlands and 93.5% of Western European origin. Of all identified subjects, 180 (1.6%) were HBV vaccine nonresponders and 549 (4.8%) were low responders. When compared with individuals aged 40 years in comparison with those younger than 40 years, P < .001. All nonresponders were born in the Netherlands. Although no significant association was found between nonresponse and individuals of Western European origin (adjusted odds ratio [aOR] = 1.20; 95% CI, 0.66-2.44; P = .163), low response to HBV vaccination was significantly associated with Western European origin (aOR = 2.21; 95% CI, 1.41-3.86; P = .001). Significant determinants for nonresponse were older age at vaccination (aOR = 1.06; 95% CI, 1.06-1.07; P < .001) and male gender (aOR = 2.51; 95% CI, 1.97-3.22; P < .001). Conclusions The nonresponse rate was low in our study population. Our findings suggest that the vaccines being used for the primary vaccination are probably less immunogenic for older individuals, males, and persons of Western European origin. foundation Limburg Sterk Merk; province of Limburg; Flemish government; Hasselt University; Ziekenhuis OostLimburg; Jessa Hospital |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text