A silicone-coated nylon dressing reduces healing time in burned paediatric patients in comparison with standard sulfadiazine treatment: a prospective randomized trial
| Autor: | C. Le Coultre, G. La Scala, A. Lironi, Aaron Vunda, Jacques Birraux, Bernard Genin, Sophia Taylor, D Gyger, P. Bugmann |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.medical_treatment Silicones Sulfadiazine Pilot Projects Occlusive Dressings Critical Care and Intensive Care Medicine Silver sulfadiazine law.invention Ointments chemistry.chemical_compound Silicone Anti-Infective Agents Coated Materials Biocompatible Randomized controlled trial law medicine Humans Prospective Studies Burns/etiology/pathology/therapy Child Prospective cohort study Wound Healing Chemotherapy ddc:618 Anti-Infective Agents/administration & dosage/therapeutic use business.industry General Medicine Surgery Occlusive dressing Nylons Treatment Outcome Sulfadiazine/administration & dosage/therapeutic use chemistry Child Preschool Emergency Medicine Skin grafting Female Burns business Follow-Up Studies medicine.drug |
| Zdroj: | Burns, Vol. 24, No 7 (1998) pp. 609-12 |
| ISSN: | 0305-4179 |
| Popis: | Mepitel is a new grid like silicone coated nylon dressing containing no additional biological compounds. We describe a prospective randomized pilot study comparing Mepitel to the standard silver sulfadiazine cream (Flamazine) dressing for the topical treatment of paediatric burns. Seventy-six children presenting within 24 h of injury with a non previously treated burn were randomly assigned to Mepitel treatment (group M) or Flamazine treatment (group F). Age, sex, surface area of burn and causal agent were noted at admission. The depth of the burn, cumulative number of dressings, presence or absence of a complete epithelial cover, infection, bleeding and allergy were noted at each dressing change. There were 41 children in group M and 35 children in group F. Five children were subsequently withdrawn from each group because they required skin grafting. Analysis of the above mentioned criteria showed no statistical difference between the two groups except for the healing time (group M: 7.58+/-3.12, group F: 11.26+/-6.02, p < 0.01) and the number of dressings (group M: 3.64+/-1.5, group F: 5.13+/-2.9, p < 0.05). Mepitel has proved to be an easy-to-remove dressing, adhering only to intact skin. The faster healing time found in the Mepitel group may be related to a direct effect of silicone on epithelial growth or to a decrease in surface-cell damage compared to the silver sulfadiazine group. This attractive product will be further assessed on a larger scale trial to confirm our observations. |
| Databáze: | OpenAIRE |
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