Phenylalanine Butyramide Is a New Cosmetic Ingredient with Soothing and Anti-Reddening Potential
| Autor: | Anna Fiorenza de Giovanni di Santa Severina, Lorella Paparo, Antonia Sacchi, Cristina Bruno, Antonietta Bernardi, Lucia Grumetto, Sonia Laneri, Serena Coppola, Irene Dini, Carmen Avagliano, Ritamaria Di Lorenzo |
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| Přispěvatelé: | di Lorenzo, Ritamaria, Bernardi, Antonietta, Grumetto, Lucia, Sacchi, Antonia, Avagliano, Carmen, Coppola, Serena, de Giovanni di Santa Severina, Anna Fiorenza, Bruno, Cristina, Paparo, Lorella, Laneri, Sonia, Dini, Irene |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Erythema
skin microbiota Phenylalanine Pharmaceutical Science Organic chemistry skin permeation Human skin Cosmetics Butyrate Protective Agents Article Analytical Chemistry Butyric acid chemistry.chemical_compound QD241-441 soothing and anti-reddening effect In vivo Drug Discovery medicine Humans erythema index Food science Physical and Theoretical Chemistry Skin Molecular Structure Butyramide integumentary system Chemistry butyrate Amides Cosmetic ingredient Chemistry (miscellaneous) Molecular Medicine medicine.symptom |
| Zdroj: | Molecules Volume 26 Issue 21 Molecules, Vol 26, Iss 6611, p 6611 (2021) |
| ISSN: | 1420-3049 |
| Popis: | Human skin is colonized by diverse commensal microbes, making up the skin microbiota (SM), contributing to skin integrity and homeostasis. Many of the beneficial effects aroused by the SM are exerted by microbial metabolites such as short-chain fatty acids (SCFAs), including butyric acid. The SCFAs can be used in cosmetic formulations against skin diseases to protect SM by preserving and/or restoring their natural balance. Unpleasant sensorial properties and unfavorable physico-chemical properties of butyrate strongly limit its cosmetic use. In contrast, some butyrate derivatives, including phenylalanine butyramide (C13H18N2O2, FBA), a solid form of butyric acid, are odorless while retaining the pharmacokinetic properties and safety profile of butyric acid. This study assessed the FBA’s permeation across the skin and its soothing and anti-reddening potential to estimate its cosmetic application. The dosage method used to estimate FBA’s levels was validated to be sure of analytical results. The FBA diffusion tests were estimated in vitro using a Franz-type vertical diffusion cell. The soothing action was evaluated in vivo by Colorimeter CL400, measuring the erythema index. The results suggest that the FBA represents an innovative way to exploit the benefits of butyric acid in the cosmetic fields since it cannot reach the bloodstream, is odorless, and has a significative soothing action (decrease the erythema index −15.7% after 30′, and −17.8% after 60′). |
| Databáze: | OpenAIRE |
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