Distance disintegration characterizes node-level topological dysfunctions in cocaine addiction
| Autor: | Juan Carlos Bustamante, Alfonso Barrós-Loscertales, Anna Miró-Padilla, Víctor Costumero, María-Ángeles Palomar-García, Juan José Llopis, Patricia Rosell Negre, Jesús Adrián-Ventura, Paola Fuentes-Claramonte, Jorge Sepulcre |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male media_common.quotation_subject graph theory Medicine (miscellaneous) cocaine Topology 03 medical and health sciences Cocaine-Related Disorders 0302 clinical medicine medicine Image Processing Computer-Assisted Humans resting state Clustering coefficient media_common Pharmacology Temporal cortex Brain Mapping Resting state fMRI Addiction Ventral striatum functional connectivity Patient Acuity Brain Cognition Middle Aged Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Connectome addiction Psychology Insula 030217 neurology & neurosurgery optimal connectivity distance |
| Zdroj: | Repositori Universitat Jaume I Universitat Jaume I |
| ISSN: | 1369-1600 |
| Popis: | Previous investigations have used global graph theory measures in order to disentangle the complexity of the neural reorganizations occurring in cocaine use disorder (CUD). However, how these global topological alterations map into individual brain network areas remains unknown. In this study, we used resting state functional magnetic resonance imaging (fMRI) data to investigate node-level topological dysfunctions in CUD. The sample was composed of 32 individuals with CUD and 32 healthy controls, matched in age, years of education and intellectual functioning. Graph theory measures of optimal connectivity distance, node strength, nodal efficiency and clustering coefficient were estimated in each participant using voxel-wise functional connectivity connectomes. CUD individuals as compared with healthy controls showed higher optimal connectivity distances in ventral striatum, insula, cerebellum, temporal cortex, lateral orbitofrontal cortex, middle frontal cortex and left hippocampus. Furthermore, clinical measures quantifying severity of dependence were positively related with optimal connectivity distances in the right rolandic operculum and the right lateral orbitofrontal cortex, whereas length of abstinence was negatively associated with optimal connectivity distances in the right temporal pole and the left insula. Our results reveal a topological distancing of cognitive and affective related areas in addiction, suggesting an overall reduction in the communication capacity of these regions. Funding for open access charge: CRUE-Universitat Jaume I This research was supported by grant 040/2011 from Spanish National Drug Strategy, Ministerio de Sanidad y Consumo to ABL. JAV was supported by a predoctoral graduate programme grant (National FPU). MPG and AMP were supported by a postdoctoral graduate programme grant (postdoc-UJI). VC was supported by grant PID2019-105077RJ-I00 from Ministerio de Ciencia, Innovación y Universidades. |
| Databáze: | OpenAIRE |
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