Migraine: Genetic Variants and Clinical Phenotypes
| Autor: | Alessandro Vacca, Lorenzo Pinessi, Innocenzo Rainero, Elisa Rubino, Annalisa Gai, Flora Govone |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Candidate gene Potassium Channels Migraine Disorders Bioinformatics Biochemistry 03 medical and health sciences 0302 clinical medicine ATP1A2 Molecular genetics Drug Discovery medicine Humans Genetic association Pharmacology biology business.industry Organic Chemistry Genetic Variation medicine.disease Phenotype NAV1.1 Voltage-Gated Sodium Channel 030104 developmental biology Migraine Methylenetetrahydrofolate reductase biology.protein Molecular Medicine Neurovascular Disorder Calcium Channels Sodium-Potassium-Exchanging ATPase business 030217 neurology & neurosurgery Genome-Wide Association Study |
| Zdroj: | Current medicinal chemistry. 26(34) |
| ISSN: | 1875-533X |
| Popis: | Migraine is a common, chronic neurovascular disorder caused by a complex interaction between genetic and environmental risk factors. In the last two decades, molecular genetics of migraine have been intensively investigated. In a few cases, migraine is transmitted as a monogenic disorder, and the disease phenotype cosegregates with mutations in different genes like CACNA1A, ATP1A2, SCN1A, KCNK18, and NOTCH3. In the common forms of migraine, candidate genes as well as genome-wide association studies have shown that a large number of genetic variants may increase the risk of developing migraine. At present, few studies investigated the genotype-phenotype correlation in patients with migraine. The purpose of this review was to discuss recent studies investigating the relationship between different genetic variants and the clinical characteristics of migraine. Analysis of genotype-phenotype correlations in migraineurs is complicated by several confounding factors and, to date, only polymorphisms of the MTHFR gene have been shown to have an effect on migraine phenotype. Additional genomic studies and network analyses are needed to clarify the complex pathways underlying migraine and its clinical phenotypes. |
| Databáze: | OpenAIRE |
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