Maternal vitamin D levels and male reproductive health: a population-based follow-up study
| Autor: | Anne Gaml-Sørensen, Nis Brix, Katia Keglberg Hærvig, Christian Lindh, Sandra Søgaard Tøttenborg, Karin Sørig Hougaard, Birgit Bjerre Høyer, Andreas Ernst, Linn Håkonsen Arendt, Pernille Jul Clemmensen, Jens Peter Ellekilde Bonde, Tine Brink Henriksen, Gunnar Toft, Onyebuchi A. Arah, Cecilia Høst Ramlau-Hansen |
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| Rok vydání: | 2023 |
| Předmět: |
Adult
Male testes volume Epidemiology Denmark Prevention Contraception/Reproduction prenatal exposure Reproductive health and childbirth Vitamin D Deficiency 25-hydroxyvitamin D reproductive hormones Semen Analysis Reproductive Health Good Health and Well Being semen quality Semen Pregnancy instrumental variable analysis Public Health and Health Services Humans Female Vitamin D Follow-Up Studies Nutrition |
| Zdroj: | Gaml-Sørensen, A, Brix, N, Hærvig, K K, Lindh, C, Tøttenborg, S S, Hougaard, K S, Høyer, B B, Ernst, A, Arendt, L H, Clemmensen, P J, Bonde, J P E, Henriksen, T B, Toft, G, Arah, O A & Ramlau-Hansen, C H 2023, ' Maternal vitamin D levels and male reproductive health : a population-based follow-up study ', European Journal of Epidemiology, vol. 38, no. 5, pp. 469-484 . https://doi.org/10.1007/s10654-023-00987-5 European journal of epidemiology, vol 38, iss 5 |
| ISSN: | 1573-7284 0393-2990 |
| Popis: | Maternal vitamin D levels during pregnancy may be important for reproductive health in male offspring by regulating cell proliferation and differentiation during development. We conducted a follow-up study of 827 young men from the Fetal Programming of Semen Quality (FEPOS) cohort, nested in the Danish National Birth Cohort to investigate if maternal vitamin D levels were associated with measures of reproductive health in adult sons. These included semen characteristics, testes volume, and reproductive hormone levels and were analysed according to maternal vitamin D (25(OH)D3) levels during pregnancy. In addition, an instrumental variable analysis using seasonality in sun exposure as an instrument for maternal vitamin D levels was conducted. We found that sons of mothers with vitamin D levels 75nmol/L. Continuous models, spline plots and an instrumental variable analysis supported these findings. Low maternal vitamin D levels were associated with lower testes volume and lower total sperm count with indications of dose-dependency. Maternal vitamin D level above 75nmol/L during pregnancy may be beneficial for testes function in adult sons. |
| Databáze: | OpenAIRE |
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