A Randomized Controlled Trial of 2 Inhalation Methods When Using a Pressurized Metered Dose Inhaler With Valved Holding Chamber
| Autor: | Manju Vatsa, Rakesh Lodha, Sushil K. Kabra, Divya Anna Stephen |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Adolescent Diaphragmatic breathing Peak Expiratory Flow Rate Critical Care and Intensive Care Medicine law.invention Breath Holding Drug Delivery Systems Randomized controlled trial law Tidal breathing Administration Inhalation Medicine Humans Albuterol Metered Dose Inhalers Child Asthma Inhalation business.industry digestive oral and skin physiology General Medicine respiratory system medicine.disease HOLDING CHAMBER Metered-dose inhaler respiratory tract diseases Bronchodilator Agents Respiratory Function Tests Anesthesia Child Preschool Salbutamol Female business circulatory and respiratory physiology medicine.drug Inhalation Spacers |
| Zdroj: | Respiratory care. 60(12) |
| ISSN: | 1943-3654 |
| Popis: | BACKGROUND: Information on the comparative efficacy of single deep breathing versus tidal breathing for inhaled asthma medications is limited, although such information can be of much use for the treatment of patients suffering from asthma. The objective of the present study was to compare the relative difference in improvement in peak expiratory flow (PEF) with single maximal inhalation with breath-holding versus 5 tidal breaths during inhalation of salbutamol from a pressurized metered dose inhaler (pMDI) with valved holding chamber (VHC) in children 5–15 y of age with asthma. METHODS: The randomized controlled trial was carried out on children with asthma between 5 and 15 y of age using a pMDI with a VHC either by a single deep breath with breath-hold or 5 tidal breaths. The experimental group received 200 μg of salbutamol from the pMDI with VHC with a single maximal inhalation and breath-hold technique, whereas the control group received 200 μg of salbutamol from pMDI with VHC using the 5 tidal breaths technique. The outcome variable, PEF, was reassessed 30 min after salbutamol use. RESULTS: Eighty-two subjects (mean age 8.79 ± 2.5 y, 65 boys and 17 girls) were analyzed. There was significant improvement in the PEF, from baseline (pre-intervention) to post-intervention within the single maximal inhalation with breath-hold group and tidal breathing group independently ( P < .001). The mean difference in improvement in PEF between the single maximal inhalation with a breath-hold and 5 tidal breaths group was 30.0 ± 18.16 and 28.29 ± 13.94 L/min, respectively, and was not statistically significant ( P = .88). CONCLUSIONS: Single maximal inhalation with a breath-hold technique is not superior to tidal breathing for improvement in PEF following salbutamol inhalation. Either method may be used in children between 5 and 15 y of age. (India's Clinical Trials Registry CTRI/2013/04/003559.) |
| Databáze: | OpenAIRE |
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