Fiber intake and pancreatic cancer risk: a case–control study
| Autor: | Jerry Polesel, Ettore Bidoli, Maurizio Montella, C. La Vecchia, Silvia Franceschi, R. Talamini, Diego Serraino, Giovanni Boz, A. Zucchetto, L. Dal Maso, Claudio Pelucchi, Eva Negri |
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| Přispěvatelé: | Bidoli E, Pelucchi C, Zucchetto A, Negri E, Dal Maso L, Polesel J, Boz G, Montella M, Franceschi S, Serraino D, La Vecchia C, Talamini R, E. Bidoli, C. Pelucchi, A. Zucchetto, E. Negri, L. Dal Maso, J. Polesel, G. Boz, M. Montella, S. Franceschi, D. Serraino, C. La Vecchia, R. Talamini |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Dietary Fiber Male medicine.medical_specialty Neuroendocrine tumors Gastroenterology Risk Factors Internal medicine Pancreatic cancer Odds Ratio medicine Humans Fiber Food science Aged Aged 80 and over business.industry Confounding Case-control study Hematology Odds ratio Middle Aged medicine.disease Confidence interval Diet Pancreatic Neoplasms Oncology Case-Control Studies Etiology Female business |
| Zdroj: | Annals of Oncology. 23:264-268 |
| ISSN: | 0923-7534 |
| Popis: | Background Scanty and inconsistent studies are available on the relation between dietary fiber intake and pancreatic cancer. A case–control study was carried out in northern Italy to further investigate the role of various types of dietary fibers in the etiology of pancreatic cancer. Patients and methods Cases were 326 patients with incident pancreatic cancer, excluding neuroendocrine tumors, admitted to major teaching and general hospitals during 1991–2008. Controls were 652 patients admitted for acute, nonneoplastic conditions to the same hospital network of cases. Information was elicited using a validated food frequency questionnaire. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were estimated for intake quintiles of different types of fiber after allowance for total energy intake and other potential confounding factors. Results Total fiber intake was inversely related to risk of pancreatic cancer (OR = 0.4 for highest versus lowest quintile of intake; 95% CI 0.2–0.7). An inverse association emerged between pancreatic cancer and both soluble (OR = 0.4; 95% CI 0.2–0.7) and total insoluble fiber (OR = 0.5; 95% CI 0.3–0.8), particularly cellulose (OR = 0.4; 95% CI 0.3–0.7) and lignin (OR = 0.5; 95% CI 0.3–0.9). Fruit fiber intake was inversely associated with pancreatic cancer (OR = 0.5; 95% CI 0.3–0.8), whereas grain fiber was not (OR = 1.2; 95% CI 0.7–2.0). Conclusions This study suggests that selected types of fiber and total fiber are inversely related to pancreatic cancer. |
| Databáze: | OpenAIRE |
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