A Microbiota-Directed Food Intervention for Undernourished Children
| Autor: | Cyrus Zhou, Jeffrey I. Gordon, Arjun S. Raman, Michael J. Barratt, Martin Meier, Sayeeda Huq, Daniel M. Webber, Vinaik Sundaresan, Tahmeed Ahmed, Matthew C. Hibberd, Nurun Nahar Naila, Mustafa Mahfuz, Subhasish Das, Robert Y. Chen, M Ashraful Alam, Kazi Badrul Ahsan, Mahabub U Zaman, Ishita Mostafa, M Munirul Islam |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Extramural
business.industry General Medicine 030204 cardiovascular system & hematology medicine.disease Body weight Article law.invention 03 medical and health sciences Malnutrition 0302 clinical medicine Randomized controlled trial law Intervention (counseling) Environmental health medicine 030212 general & internal medicine business Infant Nutritional Physiological Phenomena |
| Zdroj: | The New England Journal of Medicine |
| ISSN: | 1533-4406 0028-4793 |
| Popis: | BACKGROUND More than 30 million children worldwide suffer from moderate acute malnutrition (MAM). Current treatments have limited effectiveness and much remains unknown about pathogenesis. Children with MAM exhibit perturbed development of their gut microbiota. METHODS Slum-dwelling Bangladeshi children, aged 12 to 18 months, with moderate acute malnutrition (n=124) received a microbiota-directed complementary food (MDCF-2) or an existing ready-to-use supplementary food (RUSF), twice daily for three months followed by a 1-month period of monitoring. We obtained weight-for-length, weight-for-age, and length-for-age Z-scores and mid-upper arm circumference at baseline and fortnightly, through four months. We compared the rate of change of these related phenotypes between baseline and three months, and between baseline and four months. We also measured levels of 4,977 proteins in plasma plus 209 bacterial taxa in fecal samples. RESULTS 118 children completed the intervention (n=59/arm). The rate of change in weight-for-length Z-score (β-WLZ), weight-for-age Z-score, and mid upper arm circumference is consistent with a benefit of MDCF-2 on growth over the course of the study including the one-month follow-up. Receipt of MDCF-2 was linked to the magnitude of change in levels of 70 β-WLZ-positively correlated plasma proteins including mediators of bone growth, neurodevelopment and inflammation (gene set enrichment analysis [GSEA];p |
| Databáze: | OpenAIRE |
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