Effects of oral clenbuterol on the clinical and inflammatory response to endotoxaemia in the horse
| Autor: | Ted Whittem, Simon R. Bailey, L. Cudmore, T. Muurlink |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
Terbutaline Anti-Inflammatory Agents Administration Oral Inflammation Pharmacology Body Temperature Sepsis Leukocyte Count Therapeutic index Respiratory Rate In vivo Heart Rate Blood plasma medicine Animals Clenbuterol Horses General Veterinary business.industry Tumor Necrosis Factor-alpha medicine.disease Endotoxemia Endotoxins Hematocrit Immunology Tumor necrosis factor alpha Female Horse Diseases medicine.symptom business medicine.drug |
| Zdroj: | Research in veterinary science. 94(3) |
| ISSN: | 1532-2661 |
| Popis: | Pro-inflammatory cytokines, such as IL-1β and TNFα, play a major role in activating leukocytes and endothelial cells during the systemic inflammatory response to endotoxin in the horse. β 2 agonist drugs, such as clenbuterol, inhibit leukocyte activation. This study aimed to determine the effects of oral clenbuterol on clinical and leukocyte responses, including production of TNFα, in an in vivo endotoxin challenge model. In a randomised crossover design, horses received either clenbuterol or a placebo product prior to the administration of low dose endotoxin (30 ng/kg over 30 min). Clinical signs were measured and leukocyte counts and serial blood samples were obtained over 6 h. Pre-treatment with oral clenbuterol (0.8 μg/kg) significantly reduced ( P = 0.046) the peak rectal temperature and the peak plasma TNFα concentration ( P = 0.026) following endotoxin challenge. These data suggest that oral clenbuterol at the therapeutic dose has anti-inflammatory effects in horses challenged with a low dose of endotoxin. |
| Databáze: | OpenAIRE |
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