Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population
| Autor: | Nguyen Chi Phi, Minako Hijikata, Takehiko Sasazuki, Masahiro Satake, Satoru Itoyama, Hoang Thuy Long, Nguyen Thi Le Hang, Naoto Keicho, Vo Van Ban, Bach Khanh Hoa, Katsushi Tokunaga, Le Dang Ha, Shinsaku Sakurada, Koichi Kashiwase, Tran Quy |
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| Rok vydání: | 2009 |
| Předmět: |
Severe acute respiratory syndrome (SARS)
Genotype Immunology Population Human leukocyte antigen Biology Severe Acute Respiratory Syndrome Article Immune system Asian People Gene Frequency Genetic predisposition medicine Immunology and Allergy Humans Genetic Predisposition to Disease Allele education skin and connective tissue diseases Allele frequency education.field_of_study Polymorphism Genetic Genetic polymorphism fungi General Medicine HLA-DR Antigens medicine.disease Human leukocyte antigen (HLA) body regions Association study Vietnam Viet Nam Severe acute respiratory syndrome HLA-DRB1 Chains |
| Zdroj: | Human Immunology |
| ISSN: | 1879-1166 |
| Popis: | Excessive immune response is believed to play a role in the development of severe acute respiratory syndrome (SARS). Inhomogeneous spread of SARS led one to think of an Asian genetic predisposition and contribution of human leukocyte antigen (HLA) to the disease susceptibility. However, past case-control studies showed inconsistent results. In Viet Nam, of 62 patients with SARS, 44 participated in the present study together with 103 individuals who had contact with SARS patients and 50 without contact history. HLA-DRB1*12 was more frequently shown in SARS patients than in controls (corrected p = 0.042). HLA-DRB1*1202, the predominant allele in the Vietnamese population showed the strongest association with SARS in a dominant model (corrected p = 0.0065 and 0.0052, depending on the controls to be compared). Our results and accumulated data on HLA in the Asian populations would help in the understanding of associations with emerging infectious diseases. |
| Databáze: | OpenAIRE |
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