Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis
| Autor: | Lisa R. Young, Francis X. McCormack, Sue Byrnes, Riffat Meraj, Kathryn A. Wikenheiser-Brokamp |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Image-Guided Biopsy
medicine.medical_specialty Diffuse lung disease Lung biopsy Diagnosis Differential immune system diseases hemic and lymphatic diseases Bronchoscopy medicine Humans In patient Lymphangioleiomyomatosis business.industry General Medicine Gold standard (test) bacterial infections and mycoses medicine.disease United States HMB-45 Pulmonary lymphangioleiomyomatosis Female lipids (amino acids peptides and proteins) Radiology Tomography X-Ray Computed Transbronchial biopsy business |
| Zdroj: | Frontiers of Medicine. 6:395-405 |
| ISSN: | 2095-0225 2095-0217 |
| Popis: | Pulmonary lymphangioleiomyomatosis (LAM) is a rare cystic lung disease that targets women during their reproductive years. A confident diagnosis can often be based on clinical grounds, but diagnostic certainty requires pathological analysis. Although surgical lung biopsy is considered the gold standard for obtaining tissue in patients with diffuse lung disease, it is also associated with higher morbidity and mortality than alternative, less invasive techniques. The objective of our study was to examine the utility of transbronchial biopsy in the diagnosis of LAM. We conducted two online surveys of over 1,000 LAM patients registered with the LAM Foundation who were accessible by email. Transbronchial biopsy specimens were subsequently collected and reviewed by an expert pathologist to validate the diagnosis. We found that transbronchial biopsy has a yield of approximately 60% in patients with LAM. We conclude that transbronchial biopsy may be a safe and effective method for establishing the diagnosis of LAM, obviating the need for surgical lung biopsy in more than half of LAM patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink