Gu, a Variant of G

Autor: K. M. Beattie, Wolf W. Zuelzer, G. M. Neitzer, V. Zanardi
Rok vydání: 1971
Předmět:
Zdroj: Transfusion. 11:152-156
ISSN: 1537-2995
0041-1132
Popis: Gu, analogous to Du and Eu, is a weak variant of G appearing in a haplotype lacking C, D, and E but having es. In a preliminary survey, the red blood cells ot three of 186 Negro blood donors found negative when tested for C, D (incuding Du), and E were shown to be Gu-positive when tested with anti-CD by the antiglobulin technic. Fourteen additional examples from unrelated persons and five members of a family have been investigated in this study. All Gu-positive individuals tested are VS-positive, but V-negative, and all are Negro. Although G cells show greater antibody uptake when used to absorb anti-CD, Gu cells elute anti-G in substantially greater amounts than do G cells. Comparative studies demonstrate similarity of specificity but a difference of avidity, which could be due to the influence of es(VS) in cis position. Gu-positive bloods have been shown to stimulate the production of anti-G in Rh-negative recipients. The test for Gu can be incorporated in the test for Du by substituting anti-CD or anti-CDE for anti-D serum.
Databáze: OpenAIRE
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