Novel combination of bioactive agents in bilayered dermal patches provides superior wound healing
| Autor: | Prakriti Tayalia, Deepak Sharma, Mamatha M. Pillai, Sushama Rokade, Hiren Dandia, Rahul Checker |
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| Rok vydání: | 2021 |
| Předmět: |
Curcumin
Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Bioengineering Absorption (skin) Polyvinyl alcohol Chitosan Extracellular matrix chemistry.chemical_compound Mice Animals General Materials Science Wound Healing integumentary system Anti-Bacterial Agents Rats chemistry Polyvinyl Alcohol Polycaprolactone Biophysics Molecular Medicine Eggshell membrane Wound healing |
| Zdroj: | Nanomedicine : nanotechnology, biology, and medicine. 40 |
| ISSN: | 1549-9642 |
| Popis: | In present study, multifunctional bilayered dermal patches with antibacterial, antioxidant and anti-inflammatory properties were developed using solvent casting or electrospinning methods and compared for performance. Top layer was made up of polycaprolactone (PCL) and chitosan (CS) while bottom layer was made of polyvinyl alcohol (PVA) with curcumin nanoparticles and soluble eggshell membrane protein (SESM) as the wound healing agents. Curcumin nanoparticles showed reduction in the production of reactive oxygen species (ROS) and inflammatory cytokines and markers in mice T cells or human macrophages, confirming their antioxidant and anti-inflammatory properties while SESM improved migration of human adult dermal fibroblasts, suggesting its contribution to wound healing. The dermal patches were hemocompatible, antibacterial and also provided adequate absorption of wound exudates, support and components required for recruitment of cells and deposition of extracellular matrix to enable superior wound healing than its commercial counterpart in a rat full thickness excision wound model. |
| Databáze: | OpenAIRE |
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