Head-to-Head Comparison of Chest X-Ray/Head and Neck MRI, Chest CT/Head and Neck MRI, and 18F-FDG PET/CT for Detection of Distant Metastases and Synchronous Cancer in Oral, Pharyngeal, and Laryngeal Cancer
Autor: | Abass Alavi, Anders Thomassen, Poul Flemming Høilund-Carlsen, Janus Mølgaard Christiansen, Christian Godballe, Anne Lerberg Nielsen, Jørgen Johansen, Max Rohde, Jens Ahm Sørensen, Nina N. T. T. Nguyen, Anabel Diaz, Jon Thor Asmussen, Oke Gerke, Mie K. Nielsen |
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Rok vydání: | 2017 |
Předmět: |
Male
Thorax Neoplasm Metastasis/diagnostic imaging HNSCC Neck/diagnostic imaging 030218 nuclear medicine & medical imaging Cohort Studies 0302 clinical medicine Mouth Neoplasms/diagnostic imaging Prospective Studies Aged 80 and over Thorax/diagnostic imaging Mouth neoplasm Laryngeal Neoplasms/diagnostic imaging medicine.diagnostic_test Middle Aged Magnetic Resonance Imaging Distant metastases Positron emission tomography 030220 oncology & carcinogenesis Female Radiology Synchronous cancer MRI Adult medicine.medical_specialty PET/CT Young Adult 03 medical and health sciences Fluorodeoxyglucose F18 Journal Article medicine Humans Radiology Nuclear Medicine and imaging Aged PET-CT Head/diagnostic imaging business.industry Detection rate Reproducibility of Results Cancer Magnetic resonance imaging medicine.disease Head and neck squamous-cell carcinoma Radiography Pharyngeal Neoplasms/diagnostic imaging Positron-Emission Tomography Radiopharmaceuticals Oral pharyngeal Tomography X-Ray Computed business |
Zdroj: | Rohde, M, Nielsen, A L, Johansen, J, Sørensen, J A, Nguyen, N N T T, Diaz, A, Nielsen, M K, Asmussen, J T, Christiansen, J M, Gerke, O, Thomassen, A, Alavi, A, Høilund-Carlsen, P F & Godballe, C 2017, ' Head-to-head comparison of chest x-ray/head and neck MRI, chest CT/head and neck MRI, and (18)F-FDG-PET/CT for detection of distant metastases and synchronous cancer in oral, pharyngeal, and laryngeal Cancer ', Journal of Nuclear Medicine, vol. 58, no. 12, pp. 1919-1924 . https://doi.org/10.2967/jnumed.117.189704 |
ISSN: | 2159-662X 0161-5505 |
DOI: | 10.2967/jnumed.117.189704 |
Popis: | The purpose of this study was to determine the detection rate of distant metastasis and synchronous cancer, comparing clinically used imaging strategies based on chest x-ray 1 head and neck MRI (CXR/MRI) and chest CT 1 head and neck MRI (CHCT/MRI) with 18F-FDG PET/CT upfront in the diagnostic workup of patients with oral, pharyngeal, or laryngeal cancer. Methods: This was a prospective cohort study based on paired data. Consecutive patients with histologically verified primary head and squamous cell carcinoma at Odense University Hospital from September 2013 to March 2016 were considered for the study. Included patients underwent CXR/MRI and CHCT/MRI as well as PET/CT on the same day and before biopsy. Scans were read masked by separate teams of experienced nuclear physicians or radiologists. The true detection rate of distant metastasis and synchronous cancer was assessed for CXR/MRI, CHCT/MRI, and PET/CT. Results: A total of 307 patients were included. CXR/MRI correctly detected 3 (1%) patients with distant metastasis, CHCT/MRI detected 11 (4%) patients, and PET/CT detected 18 (6%) patients. The absolute differences of 5% and 2%, respectively, were statistically significant in favor of PET/CT. Also, PET/CT correctly detected 25 (8%) synchronous cancers, which was significantly more than CXR/MRI (3 patients, 1%) and CHCT/MRI (6 patients, 2%). The true detection rate of distant metastasis or synchronous cancer with PET/CT was 13% (40 patients), which was significantly higher than 2% (6 patients) for CXR/ MRI and 6% (17 patients) for CHCT/MRI. Conclusion: A clinical imaging strategy based on PET/CT demonstrated a significantly higher detection rate of distant metastasis or synchronous cancer than strategies in current clinical imaging guidelines, of which European ones primarily recommend CXR/MRI, whereas U.S. guidelines preferably point to CHCT/MRI in patients with head and neck squamous cell carcinoma. |
Databáze: | OpenAIRE |
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