An experimental evaluation of microcapsules for arterial chemoembolization
| Autor: | W Bechtel, S Mir, S Kudo, Kenneth C. Wright, B. Mosier, S. Wallace, D Mosier |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
medicine.medical_specialty
Antineoplastic Agents Capsules chemistry.chemical_compound Dogs Renal Artery Floxuridine medicine Animals Radiology Nuclear Medicine and imaging Cellulose chemistry.chemical_classification Wax Lactide business.industry Venous blood Polymer Monoglyceride Combined Modality Therapy Embolization Therapeutic Surgery Lactic acid chemistry visual_art visual_art.visual_art_medium business Biomedical engineering medicine.drug |
| Zdroj: | Radiology. 161:601-604 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.161.3.2947261 |
| Popis: | Microcapsules, 106 micron (range, 50-350 micron), of different capsular materials (monoglyceride, monodiglyceride, natural wax, cellulose polymer, or lactic acid polymer) with and without floxuridine (2'-deoxy-5-fluorouridine, FUDR) were intraarterially injected into dog kidneys. The drug-release characteristics of the microcapsules, as determined by analysis of renal and systemic venous blood samples over a 6-hour period, were uniphasic or multiphasic depending on the capsular material. Histologic changes of varying degrees were noted in all kidneys embolized except for those subjected to capsules of the cellulose polymer. The most striking changes were produced by the lactide polymer capsules. The potential applications of microencapsuled chemotherapeutic agents in intraarterial transcatheter treatment of cancer are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|