Night work, light exposure and melatonin on work days and days off
Autor: | Henrik A Kolstad, Vivi Schlünssen, Debra J. Skene, Stine Daugaard, Anne Helene Garde, Jakob Markvart, Jens Christoffersen, Åse Marie Hansen, Jens Peter Bonde, Helene Tilma Vistisen |
---|---|
Rok vydání: | 2017 |
Předmět: |
Adult
Male Saliva Time Factors Adolescent Light Physiology Photoperiod Workload Melatonin 03 medical and health sciences Young Adult 0302 clinical medicine Animal science Primary outcome Time of day Tandem Mass Spectrometry Physiology (medical) Work Schedule Tolerance Journal Article Medicine Humans Night work Light exposure Aged business.industry Shift Work Schedule Middle Aged Multilevel regression Circadian Rhythm 030220 oncology & carcinogenesis Female business Salivary melatonin 030217 neurology & neurosurgery Biomarkers medicine.drug Chromatography Liquid |
Zdroj: | Daugaard, S, Garde, A H, Bonde, J P E, Christoffersen, J, Hansen, Ä M, Markvart, J, Schlünssen, V, Skene, D J, Vistisen, H T & Kolstad, H A 2017, ' Night work, light exposure and melatonin on work days and days off ', Chronobiology International, vol. 34, no. 7, pp. 942-955 . https://doi.org/10.1080/07420528.2017.1327867 |
ISSN: | 1525-6073 |
Popis: | We aimed to examine the effects of night work on salivary melatonin concentration during and subsequent to night work and the mediating role of light. We included 254 day workers and 87 night workers who were followed during 322 work days and 301 days off work. Each day was defined as the 24 hour period starting from the beginning of a night shift or from waking in the mornings with day work and days off. Light levels were recorded and synchronized with diary information (start and end of sleep and work). On average, participants provided four saliva samples per day, and these were analyzed for melatonin concentration by liquid chromatography tandem mass spectrometry (LC-MS/MS). Differences between day and night workers on work days and days off were assessed with multilevel regression models with melatonin concentration as the primary outcome. All models were stratified or adjusted by time of day. For light exposure, we estimated the total, direct and indirect effects of night work on melatonin concentrations obtaining 95% confidence intervals through bootstrapping. On work days, night workers showed 15% lower salivary melatonin concentrations compared with day workers (-15.0%; 95% CI: -31.4%; 5.2%). During the night, light exposure mediated a melatonin suppression of approximately 6% (-5.9%, 95% CI: -10.2%; -1.5%). No mediating effect of light was seen during the day time. On days off, we observed no difference in melatonin concentrations between day and night workers. These findings are in accordance with a transient and partly light-mediated effect of night work on melatonin production. |
Databáze: | OpenAIRE |
Externí odkaz: |