Prognosis and Clinical Characteristics of Patients with Pancreatic Ductal Adenocarcinoma Diagnosed by Endoscopic Ultrasonography but Indeterminate on Computed Tomography
| Autor: | Seung Bae Yoon, Sung Woo Ko, Jun-Ho Choi, Tae Jun Song, Seong Hun Kim, Dong Wook Lee, Chang Min Cho, Dong Wan Seo, Jae Hee Cho, Sang Hyub Lee, Tae Hyeon Kim, Tae Hoon Lee, Jai Hoon Yoon, Hoon Jai Chun, Gwang Ha Kim |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Pancreatic duct
medicine.medical_specialty Hepatology Proportional hazards model business.industry Medical record Pancreatic Ducts Gastroenterology Prognosis digestive system diseases Confidence interval Endosonography Pancreatic Neoplasms medicine.anatomical_structure Radiological weapon Humans Medicine Radiology Tomography X-Ray Computed Indeterminate business Survival rate Survival analysis Carcinoma Pancreatic Ductal Retrospective Studies |
| Zdroj: | Gut and Liver. 16:474-482 |
| ISSN: | 2005-1212 1976-2283 |
| Popis: | Background/Aims Endoscopic ultrasonography (EUS) provides high-resolution images and is superior to computed tomography (CT) scan in diagnosing small pancreatic ductal adenocarcinoma (PDAC). As a result, the use of EUS for early detection of PDAC has attracted attention. This study aimed to identify the clinical and radiological characteristics of patients with PDAC diagnosed by EUS but not found on CT scan. Methods The medical records of patients diagnosed with PDAC at 12 tertiary referral centers in Korea from January 2003 to April 2019 were reviewed. This study included patients with pancreatic masses not clearly observed on CT scan but identified on EUS. The clinical characteristics and radiological features of the patients were analyzed, and survival analysis was performed. Results A total of 83 patients were enrolled. The most common abnormal CT findings other than a definite mass was pancreatic duct dilatation, which was identified in 61 patients (73.5%). All but four patients underwent surgery. The final pathologic stages were as follows: IA (n=31, 39.2%), IB (n=8, 10.1%), IIA (n=20, 25.3%), IIB (n=17, 21.5%), III (n=2, 2.5%), and IV (n=1, 1.4%). The 5-year survival rate of these patients was 50.6% (95% confidence interval, 38.8% to 66.7%). Elevated liver function testing and R1 resection emerged as significant predictors of mortality in the multivariable Cox regression analysis. Conclusions This multicenter study demonstrated favorable long-term prognosis in patients with PDAC diagnosed by EUS but indeterminate on CT scan. EUS should be considered for patients with suspected PDAC but indeterminate on CT scan. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|