Impact of collection method and sample handling on measured levels of circulating ACTH
| Autor: | Christophe Borin, Dieter Mesotten, Hilke Vervenne, Greet Van den Berghe |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Sample handling
endocrine system medicine.medical_specialty Pathology business.industry Adrenal gland Confounding Adrenocorticotropic hormone Critical Care and Intensive Care Medicine Endocrinology medicine.anatomical_structure Internal medicine Poster Presentation Critical illness medicine In patient business hormones hormone substitutes and hormone antagonists Severe sepsis Collection methods |
| Zdroj: | Critical Care |
| ISSN: | 1364-8535 |
| DOI: | 10.1186/cc8824 |
| Popis: | Cortisol, which is produced and released by the adrenal gland under the regulation of the adrenocorticotropic hormone (ACTH), plays a crucial role in the survival mechanisms involved in critical illness. A dissociation between high plasma cortisol and low ACTH in patients has been observed in the more chronic phase of critical illness induced by severe sepsis and multiple trauma [1]. In order to assess the potential confounding impact of errors in the measurement of ACTH, we evaluated the stability of ACTH during sample processing. |
| Databáze: | OpenAIRE |
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