Serum Leptin Levels and Lipid Profiles in Patients with Allergic Rhinitis and Mild Asthma
| Autor: | Mehmet Karaayvaz, Sami Öztürk, Mustafa Gulec, Özgür Kartal, Fatih Ors, Zafer Çalişkaner, Yasemin Gulcan Kurt, Fuat Erel, E Gocgeldic, Halil Yaman |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Leptin Male Pulmonary and Respiratory Medicine medicine.medical_specialty Rhinitis Allergic Perennial Adolescent Immunology Body Mass Index chemistry.chemical_compound Sex Factors Internal medicine Animals Humans Immunology and Allergy Medicine Prospective Studies Budesonide Prospective cohort study Asthma Triglyceride business.industry Case-control study General Medicine Immunoglobulin E Middle Aged Eosinophil medicine.disease Lipids Pathophysiology Lipoproteins LDL Endocrinology medicine.anatomical_structure chemistry Case-Control Studies Female business Body mass index |
| Zdroj: | Allergologia et Immunopathologia. 35:232-238 |
| ISSN: | 0301-0546 |
| DOI: | 10.1157/13112988 |
| Popis: | Despite improved understanding of the pathophysiology of allergic rhinitis and asthma, the effect of serum leptin level is still controversial. Only a few studies have been performed to investigate the serum leptin levels in allergic rhinitis and asthma, and contradictory results have been observed.We aimed to investigate the association between leptin, lipid profiles and allergic rhinitis and mild asthma, and to determine whether inhaled and/or intranasal steroids affect the leptin levels.We studied 43 patients with allergic rhinitis (10 of with mild asthma) (mean age 29.81, range 18-45 yr) and 32 volunteers as a control group (mean age 30.53, range 20-45 yr).Serum leptin levels in patients were 8.49 +/- 10.76 microg/ml, and did not differ from volunteers 5.42 +/- 6.63 microg/ml. (p0.05). We found a direct link between increased body mass index (BMI) and serum leptin levels (p = 0.008). No association was seen between leptin and triglyceride, HDL-cholesterol, VLDL-cholesterol, eosinophil, total IgE (p0.05); except for total cholesterol and LDL-cholesterol (p0.05). Although, no correlation between allergic rhinitis and mild asthma and serum level of leptin was shown, these parameters and age correlations were stronger in female than in male (p = 0.39 for male and p = 0.011 for female), and also found direct link between increased BMI and sex and patients group (p = 0.008 for male and p = 0.0001 for female). We also determined that there was no effect of inhaled and/or intranasal steroids statistically on serum leptin levels.Our data demonstrate that the serum levels of leptin and lipid profiles on allergic rhinitis and mild asthma were not different than those in controls. |
| Databáze: | OpenAIRE |
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