Structural Determination of NSC 670224, Synthesis of Analogues and Biological Evaluation

Autor:	Andrew S. Myers, R. Scott Lokey, Grant A. Hartzog, Nathaniel B. Zuckerman, Walter M. Bray, Tiffani K. Quan, Joseph P. Konopelski
Rok vydání:	2012
Předmět:	Drug Antineoplastic Agents Hormonal Stereochemistry High-throughput screening media_common.quotation_subject Saccharomyces cerevisiae Biology Biochemistry Article Small Molecule Libraries Inhibitory Concentration 50 Cyclohexanes Benzyl Compounds Drug Discovery medicine Humans Inhibitory concentration 50 General Pharmacology Toxicology and Pharmaceutics reproductive and urinary physiology Biological evaluation media_common Pharmacology Cell Death Dose-Response Relationship Drug Molecular Structure Drug discovery Organic Chemistry biology.organism_classification nervous system diseases Tamoxifen nervous system Mechanism of action Molecular Medicine Female biological phenomena cell phenomena and immunity medicine.symptom medicine.drug
Zdroj:	ChemMedChem. 7:761-765
ISSN:	1860-7179
DOI:	10.1002/cmdc.201200038
Popis:	Follow my lead! NSC 670224, previously shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related to that of tamoxifen (NSC 180973), breast cancer drug. The structure of NSC 670224, previously thought to be a 2,4-dichloro arene, was established as the 3,4-dichloro arene, and a focused library of analogues were synthesized and biologically evaluated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b832cfe7b5b7cb1837db5a03d86c17 https://doi.org/10.1002/cmdc.201200038 Zobrazit plný text záznamu Plný text