Changes in CD163+, CD11b+, and CCR2+ peripheral monocytes relate to Parkinson’s disease and cognition
| Autor: | David Goldeck, Farmen K, Sara K. Nissen, Kathrin Brockmann, Marina Romero-Ramos, Claudia Schulte, Carstensen M |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Male
metabolism [Receptors CCR2] Receptors CCR2 metabolism [Toll-Like Receptor 2] Phagocytosis Parkinson's disease Immunology metabolism [Parkinson Disease] Antigens Differentiation Myelomonocytic Receptors Cell Surface Disease Peripheral blood mononuclear cell Dendritic cells Monocytes Alpha-synuclein Behavioral Neuroscience Cognition Immune system ddc:150 Neuroinflammation Antigens CD TLR medicine Humans biology business.industry Endocrine and Autonomic Systems Monocyte Neurodegeneration Parkinson Disease medicine.disease Toll-Like Receptor 2 Cross-Sectional Studies medicine.anatomical_structure Integrin alpha M Parkinson’s disease biology.protein Natural killer cells Female business CD163 Biomarkers metabolism [Biomarkers] metabolism [Monocytes] |
| Zdroj: | Konstantin Nissen, S, Farmen, K, Carstensen, M, Schulte, C, Goldeck, D, Brockmann, K & Romero-Ramos, M 2022, ' Changes in CD163+, CD11b+, and CCR2+ peripheral monocytes relate to Parkinson's disease and cognition ', Brain, Behavior, and Immunity, vol. 101, pp. 182-193 . https://doi.org/10.1016/j.bbi.2022.01.005 Brain, behavior and immunity 101, 182-193 (2022). doi:10.1016/j.bbi.2022.01.005 |
| ISSN: | 0889-1591 |
| Popis: | 1.AbstractAlpha-synuclein pathology is associated with immune activation and neurodegeneration in Parkinson’s disease. The immune activation involves not only microglia but also peripheral immune cells, such as mononuclear phagocytes found in blood and infiltrated in the brain. Understanding peripheral immune involvement is essential for developing immunomodulatory treatment. Therefore, we aimed to study circulating mononuclear phagocytes in early- and late-stage Parkinson’s disease, defined by disease duration of less or more than five years, respectively, and analyze their association with clinical phenotypes. We performed a cross-sectional multi-color flow cytometry study on 78 sex-balanced individuals with sporadic Parkinson’s disease, 28 controls, and longitudinal samples from seven patients and one control. Cell frequencies and surface marker expressions on natural killer cells, monocyte subtypes, and dendritic cells were compared between groups and correlated with standardized clinical scores. We found elevated frequencies and surface levels of migration-(CCR2, CD11b) and phagocytic-(CD163) markers, particularly on classical and intermediate monocytes in early Parkinson’s disease. HLA-DR expression was increased in advanced stages of the disease, whereas TLR4 expression was decreased in women with Parkinson’s Disease. The disease-associated immune changes on CCR2 and CD11b correlated with worse cognition. Increased TLR2 expression was related to worse motor symptoms. In conclusion, our data highlights the TLR2 relevance in the symptomatic motor presentation of the disease and a role for peripheral CD163+ and migration-competent monocytes in Parkinson’s disease cognitive defects. Our study suggests that the peripheral immune system is dynamically altered in Parkinson’s disease stages and directly related to both symptoms and the sex bias of the disease.HighlightsTLR2 expression increased in patients with worse motor symptoms.Increased CD163 and HLA-DR monocytic expression in patients with long PD duration.Sexual-dimorphism for CCR2, CD11b, and TLR4 expression on PD monocytes.CCR2 and CD11b expression are associated with cognitive impairment in PD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect