Survey of the current status of subclinical coronavirus disease 2019 (COVID-19)
Autor: | Yoshiyuki Watanabe, Ikuro Matsuba, Masanori Nishikawa, Hisakazu Degawa, Yoko Matsuzawa, Tetsuo Nishikawa, Norihiko Koido, Futoshi Ebara, Yoshiaki Ono, Akira Kanamori, Nobuo Hatori, Tomoyuki Kunishima |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) Medical institution medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Pneumonia Viral 030106 microbiology Antibodies Viral Chromatography Affinity Betacoronavirus 03 medical and health sciences 0302 clinical medicine Japan SARS-CoV-2 IgG antibody Surveys and Questionnaires Internal medicine Humans Medicine Pharmacology (medical) 030212 general & internal medicine Patient group Asymptomatic Infections Pandemics Aged Subclinical infection biology SARS-CoV-2 business.industry Significant difference COVID-19 Middle Aged Vaccination Infectious Diseases Immunoglobulin G Epidemiological survey biology.protein Female Original Article Immunochromatography Antibody Coronavirus Infections business |
Zdroj: | Journal of Infection and Chemotherapy |
ISSN: | 1341-321X |
Popis: | Objectives We investigated relationships between subclinical COVID-19 (coronavirus disease 2019) and background factors. Methods We determined SARS-CoV-2 antibody (IgG) prevalence in 1603 patients, doctors, and nurses in 65 medical institutions in Kanagawa Prefecture, Japan and investigated their background factors. Antibodies (IgG) against SARS-CoV-2 were analyzed by Immunochromatographic test. Results The 39 subjects (2.4%) were found to be IgG antibody-positive: 29 in the patient group (2.9%), 10 in the doctor/nurse group (2.0%), and 0 in the control group. After adjustment for age, sex, and the antibody prevalence in the control group, antibody prevalence was 2.7% in the patient group and 2.1% in the doctor/nurse group. There was no significant difference between the antibody-positive subjects and the antibody-negative subjects in any background factors investigated including overseas travel, contact with overseas travelers, presence/absence of infected individuals in the living area, use of trains 5 times a week or more, BCG vaccination, and use of ACE inhibitor and ARB. Conclusions Antibody prevalence in the present survey at medical institution is higher than that in Tokyo and in Osaka measured by the government suggesting that subclinical infections are occurring more frequently than expected. No background factor that influenced antibody-positive status due to subclinical infection was identified. |
Databáze: | OpenAIRE |
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