Survey of the current status of subclinical coronavirus disease 2019 (COVID-19)

Autor: Yoshiyuki Watanabe, Ikuro Matsuba, Masanori Nishikawa, Hisakazu Degawa, Yoko Matsuzawa, Tetsuo Nishikawa, Norihiko Koido, Futoshi Ebara, Yoshiaki Ono, Akira Kanamori, Nobuo Hatori, Tomoyuki Kunishima
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
Microbiology (medical)
Medical institution
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Pneumonia
Viral
030106 microbiology
Antibodies
Viral
Chromatography
Affinity
Betacoronavirus
03 medical and health sciences
0302 clinical medicine
Japan
SARS-CoV-2 IgG antibody
Surveys and Questionnaires
Internal medicine
Humans
Medicine
Pharmacology (medical)
030212 general & internal medicine
Patient group
Asymptomatic Infections
Pandemics
Aged
Subclinical infection
biology
SARS-CoV-2
business.industry
Significant difference
COVID-19
Middle Aged
Vaccination
Infectious Diseases
Immunoglobulin G
Epidemiological survey
biology.protein
Female
Original Article
Immunochromatography
Antibody
Coronavirus Infections
business
Zdroj: Journal of Infection and Chemotherapy
ISSN: 1341-321X
Popis: Objectives We investigated relationships between subclinical COVID-19 (coronavirus disease 2019) and background factors. Methods We determined SARS-CoV-2 antibody (IgG) prevalence in 1603 patients, doctors, and nurses in 65 medical institutions in Kanagawa Prefecture, Japan and investigated their background factors. Antibodies (IgG) against SARS-CoV-2 were analyzed by Immunochromatographic test. Results The 39 subjects (2.4%) were found to be IgG antibody-positive: 29 in the patient group (2.9%), 10 in the doctor/nurse group (2.0%), and 0 in the control group. After adjustment for age, sex, and the antibody prevalence in the control group, antibody prevalence was 2.7% in the patient group and 2.1% in the doctor/nurse group. There was no significant difference between the antibody-positive subjects and the antibody-negative subjects in any background factors investigated including overseas travel, contact with overseas travelers, presence/absence of infected individuals in the living area, use of trains 5 times a week or more, BCG vaccination, and use of ACE inhibitor and ARB. Conclusions Antibody prevalence in the present survey at medical institution is higher than that in Tokyo and in Osaka measured by the government suggesting that subclinical infections are occurring more frequently than expected. No background factor that influenced antibody-positive status due to subclinical infection was identified.
Databáze: OpenAIRE
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