Structural Analysis of the Bulbospongiosus Muscle in Patients With Bulbar Urethral Strictures
| Autor: | Francisco J.B. Sampaio, Luciano A. Favorito, Edilaine F. Alves, Carla B. M. Gallo, Waldemar S. Costa |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Penile Diseases Urethral stricture Urology Urethroplasty medicine.medical_treatment Bulbospongiosus muscle 030232 urology & nephrology Constriction Pathologic 03 medical and health sciences Postoperative Complications 0302 clinical medicine Urethra medicine Humans Penile cancer Body Weights and Measures Correlation of Data Urethrostomy Urethral Stricture business.industry Middle Aged Plastic Surgery Procedures medicine.disease Immunohistochemistry Hypospadias 030220 oncology & carcinogenesis Elasticity Imaging Techniques Urologic Surgical Procedures business Bulbar urethral stricture Brazil Penis Open Prostatectomy |
| Zdroj: | Urology. 137:183-189 |
| ISSN: | 0090-4295 |
| DOI: | 10.1016/j.urology.2019.11.046 |
| Popis: | OBJECTIVE To characterize the bulbospongiosus muscle (BSM) in patients with bulbar urethral strictures. MATERIALS AND METHODS We studied 21 patients divided into 2 groups: Stricture Group (n = 14; mean age = 62.00 years) with bulbar stricture submitted to open urethroplasty; and Control Group (n = 7; mean age = 60.14 years) with penile strictures (hypospadias cripples, penile cancer and/or penile infection) who were submitted to perineal urethrostomy. Samples of the BSM were dissected and histologic sections were stained by histochemical and immunohistochemical techniques. Histomorphometric analyzes were performed on photomicrographs. Means were statistically compared using the unpaired Student t test and the Mann-Whitney test (P RESULTS The etiology of bulbar urethral stricture was idiopathic in 2 cases (14.29%), post-TURP in 6 (42.86%), post open radical prostatectomy in 5 (35.71%) and post open prostatectomy in 1 case (7.14%). The average length of the stricture was 2.08 cm. The only parameter analyzed with significant difference between the groups was the vessels (significant difference between the control group: 5.11 ± 1.98% and stricture group: 3.57 ± 1.32%, P = .0460). The quantitative analysis of collagen (Control Group: 10.63 ± 5.37% and Stricture Group: 10.83 ± 4.55%, P = .9296); diameter of BSM muscle fibers (Control Group: 41.71 ± 14.63 µm and Stricture Group: 40.11 ± 8.59 µm, P = .76 and elastic system fibers (Control Group; 3.83 ± 1.54% and Stricture Group: 5.43 ± 2.90%, P = .2601) showed no significant difference. CONCLUSIONS Histologic analysis showed a significant decrease of the BSM vessels in urethral stricture, without changes in elastic fibers, collagen, nerves, and muscle fiber diameter. These findings show that the bulbar urethral stricture causes minimal alterations in the structure of the BSM. |
| Databáze: | OpenAIRE |
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