Refractory pain in a schizophrenic patient on clozapine
| Autor: | Edgar Asiimwe, Csilla Feher, Emily DeFraites |
|---|---|
| Rok vydání: | 2023 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty medicine.diagnostic_test Side effect business.industry Psychological intervention Physical examination General Medicine medicine.disease Pain Intractable Refractory Schizophrenia medicine Maintenance phase Humans medicine.symptom Myopathy business Clozapine medicine.drug Antipsychotic Agents |
| Zdroj: | BMJ case reports. 14(10) |
| ISSN: | 1757-790X |
| Popis: | A 36-year-old man with schizophrenia, on two times per day clozapine, presented with a 2-year history of diffuse intermittent body pain.Per chart review—and on presentation—his physical examination had been consistently unremarkable, without point-tenderness elicited at any major muscle groups or focal neurological deficits. Workup for myopathy, neuropathy and supratherapeutic clozapine levels had similarly been unrevealing.Given that prior interventions had been unsuccessful in alleviating these symptoms, we queried whether clozapine might have been contributory. As a result, we adopted a previously described strategy of scheduling the bulk of patients’ medication during non-waking hours.At 1-month follow-up, the patient reported about a 50% improvement in his symptoms. At 6-month follow-up, this improvement in symptoms had been sustained.Our findings add to the limited anecdotal reports of this side effect whose true prevalence remains unknown. Timely recognition has the potential to promote adherence to therapy among patients in the maintenance phase. |
| Databáze: | OpenAIRE |
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