Diabetic Retinopathy Predicts Risk of Alzheimer's Disease: A Danish Registry-Based Nationwide Cohort Study

Autor: Frederik Nørregaard Pedersen, Lonny Stokholm, Frans Pouwer, Katrine Hass Rubin, Tunde Peto, Ulrik Frydkjær-Olsen, Anne Suhr Thykjær, Nis Andersen, Jens Andresen, Toke Bek, Morten La Cour, Steffen Heegaard, Kurt Højlund, Ryo Kawasaki, Javad Nouri Hajari, Kirsten Ohm Kyvik, Caroline Schmidt Laugesen, Katja Christina Schielke, Rafael Simó, Jakob Grauslund
Přispěvatelé: Institut Català de la Salut, [Pedersen FN] Department of Ophthalmology, Odense University Hospital, Odense, Denmark. Department of Clinical Research, University of Southern Denmark, Odense, Denmark. [Stokholm L, Hass Rubin K] Department of Clinical Research, University of Southern Denmark, Odense, Denmark. OPEN – Open Patient Data Explorative Network, Odense University Hospital & University of Southern Denmark, Odense, Denmark. [Pouwer F] Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark. Department of Psychology, University of Southern Denmark, Odense, Denmark. [Peto T] Department of Clinical Research, University of Southern Denmark, Odense, Denmark. Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, Northern Ireland, UK. [Frydkjær-Olsen U] Department of Ophthalmology, Lillebaelt Hospital, Vejle, Denmark. [Simó R] Servei d’Endocrinologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBERDEM (ISCIII), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Medical psychology
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia::Alzheimer Disease [DISEASES]
localizaciones geográficas::Europa (continente)::Escandinavia::Dinamarca [DENOMINACIONES GEOGRÁFICAS]
Denmark
técnicas de investigación::métodos epidemiológicos::estadística como asunto::probabilidad::riesgo::factores de riesgo [TÉCNICAS Y EQUIPOS ANALÍTICOS
DIAGNÓSTICOS Y TERAPÉUTICOS]
Diabetic Retinopathy/epidemiology
Cohort Studies
Alzheimer Disease/epidemiology
SDG 3 - Good Health and Well-being
Alzheimer Disease
Risk Factors
Diabetes Mellitus
Humans
Registries
cognitive impairment
Eye Diseases::Retinal Diseases::Diabetic Retinopathy [DISEASES]
Diabetic Retinopathy
General Neuroscience
DEMENTIA
General Medicine
oftalmopatías::enfermedades de la retina::retinopatía diabética [ENFERMEDADES]
Alzheimer's disease
Denmark/epidemiology
Psychiatry and Mental health
Clinical Psychology
diabetic retinopathy
enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::demencia::enfermedad de Alzheimer [ENFERMEDADES]
Retinopatia diabètica
diabetes mellitus
Alzheimer
Malaltia d' - Factors de Risc - Dinamarca
Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [ANALYTICAL
DIAGNOSTIC AND THERAPEUTIC TECHNIQUES
AND EQUIPMENT]
Geriatrics and Gerontology
Alzheimer’s disease
Geographic Locations::Europe::Scandinavian and Nordic Countries::Denmark [GEOGRAPHICALS]
Zdroj: Pedersen, F N, Stokholm, L, Pouwer, F, Hass Rubin, K, Peto, T, Frydkjær-Olsen, U, Thykjær, A S, Andersen, N, Andresen, J, Bek, T, La Cour, M, Heegaard, S, Højlund, K, Kawasaki, R, Hajari, J N, Ohm Kyvik, K, Laugesen, C S, Schielke, K C, Simó, R & Grauslund, J 2022, ' Diabetic Retinopathy Predicts Risk of Alzheimer's Disease: A Danish Registry-Based Nationwide Cohort Study ', Journal of Alzheimer's disease : JAD, vol. 86, no. 1, pp. 451-460 . https://doi.org/10.3233/JAD-215313
Pedersen, F N, Stokholm, L, Pouwer, F, Rubin, K H, Peto, T, Frydkjaer-Olsen, U, Thykjaer, A S, Andersen, N, Andresen, J, Bek, T, La Cour, M, Heegaard, S, Hojlund, K, Kawasaki, R, Hajari, J N, Kyvik, K O, Laugesen, C S, Schielke, K C, Simo, R & Grauslund, J 2022, ' Diabetic Retinopathy Predicts Risk of Alzheimer's Disease : A Danish Registry-Based Nationwide Cohort Study ', Journal of Alzheimer's Disease, vol. 86, no. 1, pp. 451-460 . https://doi.org/10.3233/JAD-215313
Pedersen, F N, Stokholm, L, Pouwer, F, Hass Rubin, K, Peto, T, Frydkjær-Olsen, U, Thykjær, A S, Andersen, N, Andresen, J, Bek, T, La Cour, M, Heegaard, S, Højlund, K, Kawasaki, R, Hajari, J N, Ohm Kyvik, K, Laugesen, C S, Schielke, K C, Simó, R & Grauslund, J 2022, ' Diabetic Retinopathy Predicts Risk of Alzheimer's Disease : A Danish Registry-Based Nationwide Cohort Study ', Journal of Alzheimer's Disease, vol. 86, no. 1, pp. 451-460 . https://doi.org/10.3233/JAD-215313
Scientia
Pedersen, F N, Stokholm, L, Pouwer, F, Hass Rubin, K, Peto, T, Frydkjær-Olsen, U, Thykjær, A S, Andersen, N, Andresen, J, Bek, T, La Cour, M, Heegaard, S, Højlund, K, Kawasaki, R, Hajari, J N, Ohm Kyvik, K, Laugesen, C S, Schielke, K C, Simó, R & Grauslund, J 2022, ' Diabetic Retinopathy Predicts Risk of Alzheimer's Disease: A Danish Registry-Based Nationwide Cohort Study ', JAD: Journal of Alzheimer's Disease, vol. 86, no. 1, pp. 451-460 . https://doi.org/10.3233/JAD-215313
Pedersen, F N, Stokholm, L, Pouwer, F, Hass Rubin, K, Peto, T, Frydkjær-Olsen, U, Thykjær, A S, Andersen, N, Andresen, J, Bek, T, La Cour, M, Heegaard, S, Højlund, K, Kawasaki, R, Hajari, J N, Ohm Kyvik, K, Laugesen, C S, Schielke, K C, Simó, R & Grauslund, J 2022, ' Diabetic Retinopathy Predicts Risk of Alzheimer's Disease : A Danish Registry-Based Nationwide Cohort Study ', Journal of Alzheimer's disease : JAD, vol. 86, no. 1, pp. 451-460 . https://doi.org/10.3233/JAD-215313
Journal of Alzheimer's Disease, 86(1), 451-460. IOS Press
Pedersen, F N R, Stokholm, L, Pouwer, F, Hass Rubin, K, Peto, T, Frydkjær-Olsen, U, Thykjær, A S, Andersen, N, Andresen, J, Bek, T, la Cour, M, Heegaard, S, Højlund, K, Kawasaki, R, Hajari, J N, Ohm Kyvik, K, Laugesen, C S, Schielke, K C, Simó, R & Grauslund, J 2022, ' Diabetic Retinopathy Predicts Risk of Alzheimer's Disease : A Danish Registry-Based Nationwide Cohort Study ', Journal of Alzheimer's Disease, vol. 86, no. 1, pp. 451-460 . https://doi.org/10.3233/JAD-215313
ISSN: 1387-2877
DOI: 10.3233/JAD-215313
Popis: Cognitive impairment; Diabetes mellitus; Diabetic retinopathy Discapacidad cognitiva; Diabetes mellitus; Retinopatía diabética Discapacitat cognitiva; Diabetis mellitus; Retinopatia diabètica Background: Retinal neurodegeneration is evident in early diabetic retinopathy (DR) which may be associated with other neurodegenerative diseases like Alzheimer's disease (AD). Objective: To investigate diabetes and DR as a risk marker of present and incident AD. Methods: A register-based cohort study was performed. We included 134,327 persons with diabetes above 60 years of age, who had attended DR screening, and 651,936 age- and gender-matched persons without diabetes. Results: At baseline, the prevalence of AD was 0.7% and 1.3% among patients with and without diabetes, respectively. In a multivariable regression model, patients with diabetes were less likely to have AD at baseline (adjusted OR 0.63, 95% CI 0.59–0.68). During follow-up, incident AD was registered for 1473 (0.35%) and 6,899 (0.34%) persons with and without diabetes, respectively. Compared to persons without diabetes, persons with diabetes and no DR had a lower risk to develop AD (adjusted HR 0.87, 95% CI 0.81–0.93), while persons with diabetes and DR had higher risk of AD (adjusted HR 1.24, 95% CI 1.08–1.43). When persons with diabetes and no DR were used as references, a higher risk of incident AD was observed in persons with DR (adjusted HR 1.34, 95% CI 1.18–1.53). Conclusion: Individuals with diabetes without DR were less likely to develop AD compared to persons without diabetes. However, individuals with DR had a 34% higher risk of incident AD, which raise the question whether screening for cognitive impairment should be done among individuals with DR. This work was supported by VELUX FONDEN (grant number 00028744) and Odense University Hospital PhD Foundation (grant number 4339).
Databáze: OpenAIRE
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