An ent-Kaurane-Type Diterpene in Croton antisyphiliticus Mart
| Autor: | Ana Maria Soares Pereira, Suzelei C. França, Silvia H. Taleb-Contini, Paulo Pereira, Bianca Waléria Bertoni, Sarazete Izidia Vaz Pereira, Juliana da Silva Coppede |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Staphylococcus aureus
Pharmaceutical Science Microbial Sensitivity Tests medicine.disease_cause Plant Roots Article diterpene Analytical Chemistry Microbiology chemistry.chemical_compound Drug Discovery Escherichia coli medicine Physical and Theoretical Chemistry Plants Medicinal Euphorbiaceae antibacterial Cerrado Chloroform Molecular Structure biology Traditional medicine Plant Extracts Solid Phase Extraction Organic Chemistry biology.organism_classification Antimicrobial Croton Anti-Bacterial Agents chemistry Phytochemical Chemistry (miscellaneous) Solvents Molecular Medicine Diterpenes Diterpene |
| Zdroj: | Molecules; Volume 17; Issue 8; Pages: 8851-8858 Molecules |
| ISSN: | 1420-3049 |
| Popis: | Croton antisyphiliticus is a medicinal plant widely used in the treatment of microbial infections, especially those affecting the genital tract. Crude extract, fractions and pure compound isolated from roots of this species were investigated to validate their antimicrobial activity against Escherichia coli and Staphylococcus aureus. The compound ent-kaur-16-en-18-oic acid was isolated as a major component (0.7% of crude extract), and its MIC value determined against S. aureus (ATCC 6538) was 250 μg/mL. This is the first phytochemical work on the species monitored with antimicrobial assay. |
| Databáze: | OpenAIRE |
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