Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor α and estrogen receptor β
| Autor: | Ana B. Ropero, Esther Fuentes, Bernat Soria, Angel Nadal, Ouahiba Laribi, Marjorie Maillet |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Estrogen receptor Receptors Cell Surface Biology Xenobiotics Islets of Langerhans Mice chemistry.chemical_compound Cell surface receptor Internal medicine medicine Animals Estrogen Receptor beta Binding site Receptor Estrogen receptor beta Binding Sites Multidisciplinary Estradiol Estrogen Receptor alpha Biological Sciences Immunohistochemistry Xenoestrogen Endocrinology Receptors Estrogen chemistry Calcium Estrogen-related receptor gamma Estrogen receptor alpha Protein Binding |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.97.21.11603 |
| Popis: | The molecular mechanism used by environmental chemicals to exert their hormone-like actions is still only partially resolved. Although it generally is accepted that xenoestrogens act at the genomic level by binding to intracellular estrogen receptors, we have shown here that they trigger nongenomic effects in pancreatic beta cells. Both xenoestrogens and the circulating hormone, 17beta-estradiol, bind with high affinity to a common membrane binding site unrelated to the intracellular estrogen receptors ERalpha and ERbeta. This binding site is shared by dopamine, epinephrine, and norepinephrine and has the pharmacological profile of the gammaadrenergic receptor. This study provides an outline of the membrane receptor involved in rapid xenoestrogen actions. |
| Databáze: | OpenAIRE |
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