Synthesis and biological evaluation of piperazine-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
| Autor: | Bin Ye, Yuo-Ling Chou, Rushad Karanjawala, Wheeseong Lee, Shou-Fu Lu, Kenneth J. Shaw, Steven Jones, Dao Lentz, Amy Liang, Jih-Lie Tseng, Qingyu Wu, Zuchun Zhao |
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| Rok vydání: | 2004 |
| Předmět: |
Molecular Structure
Fibrinolysis Organic Chemistry Clinical Biochemistry Drug Evaluation Preclinical Pharmaceutical Science Biochemistry Piperazines Rats Structure-Activity Relationship Drug Discovery Plasminogen Activator Inhibitor 1 Molecular Medicine Animals Blood Coagulation Tests Molecular Biology |
| Zdroj: | Bioorganicmedicinal chemistry letters. 14(3) |
| ISSN: | 0960-894X |
| Popis: | Compound 2 was identified by high throughput screening as a novel PAI-1 inhibitor. Systematic optimization of the A, B, and C segments of 2 resulted in the identification of a more potent compound 39 with good oral bioavailability. The synthesis and SAR data are presented in this report. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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