Plasmonic silver nanoshells for drug and metabolite detection
| Autor: | Xuming Sun, Ruoping Chen, Yan Li, Yu Liu, Vadanasundari Vedarethinam, Lin Huang, Kun Qian, Xiang Wei, Jingjing Wan, Ru Zhang, Deepanjali D. Gurav, Jingyi Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Drug
Silver Metabolite media_common.quotation_subject Science General Physics and Astronomy Nanotechnology 02 engineering and technology 010402 general chemistry Infections 01 natural sciences General Biochemistry Genetics and Molecular Biology Silver nanoparticle Article Drug detection chemistry.chemical_compound Postoperative Complications Pharmacokinetics Humans Sample preparation Plasmon media_common Brain Diseases Multidisciplinary Clinical Laboratory Techniques Nanoshells General Chemistry 021001 nanoscience & nanotechnology Nanoshell 0104 chemical sciences Glucose chemistry Pharmaceutical Preparations 0210 nano-technology Biomedical engineering |
| Zdroj: | Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | In-vitro metabolite and drug detection rely on designed materials-based analytical platforms, which are universally used in biomedical research and clinical practice. However, metabolic analysis in bio-samples needs tedious sample preparation, due to the sample complexity and low molecular abundance. A further challenge is to construct diagnostic tools. Herein, we developed a platform using silver nanoshells. We synthesized SiO2@Ag with tunable shell structures by multi-cycled silver mirror reactions. Optimized nanoshells achieved direct laser desorption/ionization mass spectrometry in 0.5 μL of bio-fluids. We applied these nanoshells for disease diagnosis and therapeutic evaluation. We identified patients with postoperative brain infection through daily monitoring and glucose quantitation in cerebrospinal fluid. We measured drug distribution in blood and cerebrospinal fluid systems and validated the function of blood-brain/cerebrospinal fluid-barriers for pharmacokinetics. Our work sheds light on the design of materials for advanced metabolic analysis and precision diagnostics. Preparation of samples for diagnosis can affect the detection of biomarkers and metabolites. Here, the authors use a silver nanoparticle plasmonics approach for the detection of biomarkers in patients as well as investigate the distribution of drugs in serum and cerebral spinal fluid. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|