Evaluation of mutagenic and cytotoxic effects of sodium fluoride on mammalian cells influenced by an acid environment
| Autor: | Ruppová K, Alena Gábelová, Darina Slamenova, Ladislava Wsolova |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
endocrine system
Hypoxanthine Phosphoribosyltransferase Health Toxicology and Mutagenesis Hamster Gene mutation Toxicology Cell Line chemistry.chemical_compound Cricetulus Cricetinae Sodium fluoride Cytotoxic T cell Animals Cytotoxicity Mutagenicity Tests fungi food and beverages Cell Biology DNA Hydrogen-Ion Concentration Hydrogen fluoride In vitro chemistry Biochemistry Toxicity Sodium Fluoride Acids Mutagens |
| Zdroj: | Cell biology and toxicology. 12(1) |
| ISSN: | 0742-2091 |
| Popis: | The mutagenic activity of sodium fluoride at reduced pH was studied in the V79/HGPRT system. Statistical analysis of the results of mutagenicity testing suggests that, despite its high toxicity, sodium fluoride has no mutagenic effects at reduced pH on hamster V79 cells. Short-term treatment of cells with sodium fluoride at reduced pH inhibits growth activity of cells as well as synthesis of pulse-labeled nascent DNA and cumulative RNA synthesis and proteosynthesis. From the results of this study we suggest that an acid environment which supports formation of hydrogen fluoride increases toxic but not mutagenic potencies of sodium fluoride. |
| Databáze: | OpenAIRE |
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