Influence of single nucleotide polymorphisms among cigarette smoking and non-smoking patients with coronary artery disease, urinary bladder cancer and lung cancer

Autor: Freddi Lewin, Levar Shamoun, Jan-Erik Karlsson, Bengt-Åke Andersson, Magnus Kentsson, Sture Löfgren, Shariel Sayardoust, Lars Erik Rutqvist, David Robinsson, Matida Fagerberg, Mats Nilsson, Nongnit Laytragoon Lewin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Lung Neoplasms
Pulmonology
Epidemiology
Single Nucleotide Polymorphisms
medicine.medical_treatment
Social Sciences
Coronary Artery Disease
Disease
Cardiovascular Medicine
Vascular Medicine
Lung and Intrathoracic Tumors
Suppressor Genes
Coronary artery disease
Habits
XRCC1
Medical Conditions
Smoking Habits
Medicine and Health Sciences
Psychology
Coronary Heart Disease
Public and Occupational Health
Cardiac and Cardiovascular Systems
Multidisciplinary
Kardiologi
Cancer Risk Factors
Middle Aged
Oncology
Cardiovascular Diseases
Medicine
Female
Research Article
medicine.medical_specialty
Substance-Related Disorders
Tumor Suppressor Genes
Science
Cardiology
Single-nucleotide polymorphism
Polymorphism
Single Nucleotide
Cigarette Smoking
Respiratory Disorders
Gene Types
Internal medicine
Mental Health and Psychiatry
Genetics
medicine
Humans
SNP
Genetic Predisposition to Disease
Risk factor
Lung cancer
Aged
Behavior
business.industry
Biology and Life Sciences
Smoking Related Disorders
Cancers and Neoplasms
Human Genetics
medicine.disease
Urinary Bladder Neoplasms
Case-Control Studies
Medical Risk Factors
Smoking cessation
business
Zdroj: PLoS ONE, Vol 16, Iss 1, p e0243084 (2021)
PLoS ONE
Popis: Introduction Cigarette smoke is suggested to be a risk factor for coronary artery disease (CAD), urinary bladder cancer (UBCa) or lung cancer (LCa). However, not all heavy smokers develop these diseases and elevated cancer risk among first-degree relatives suggests an important role of genetic factor. Methods Three hundred and ten healthy blood donors (controls), 98 CAD, 74 UBCa and 38 LCa patients were included in this pilot study. The influence of 92 single nucleotide polymorphisms (SNPs) and impact of cigarette smoking were analysed. Results Out of 92 SNPs tested, differences in distribution of 14 SNPs were detected between controls and patient groups. Only CTLA4 rs3087243 showed difference in both CAD and UBCa patient group compared to control group. Stratified by smoking status, the impact of smoking was associated to frequencies of 8, 3 and 4 SNPs in CAD, UBCa, LCa patients, respectively. None of these 92 SNPs showed a statistically significant difference to more than one type of disease among smoking patients. In non-smoking patients, 7, 3 and 6 SNPs were associated to CAD, UBCa, LCa, respectively. Out of these 92 SNPs, CTLA4 rs3087243 was associated to both non-smoking CAD and UBCa. The XRCC1 rs25487 was associated to both non-smoking UBCa and LCa. Conclusion SNPs might be important risk factors for CAD, UBCa and LCa. Distribution of the SNPs was specific for each patient group, not a random event. Impact of cigarette smoking on the disease was associated to the specific SNP sequences. Thus, smoking individuals with SNPs associated to risk of these serious diseases is an important target group for smoking cessation programs.
Databáze: OpenAIRE
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