Some pharmacological studies with scorpion (Pandinus exitialis) venom
| Autor: | M. A. Karrar, O.H. Osman, M. Ismail, K.A. Gumaa |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Electrophoresis
Contraction (grammar) Chromatography Paper Guinea Pigs Neuromuscular Junction Methysergide Scorpion Blood Pressure Venom Stimulation In Vitro Techniques Pharmacology Toxicology complex mixtures Median lethal dose Lethal Dose 50 Scorpions Mice Species Specificity biology.animal Intestine Small medicine Animals biology Venoms Chemistry Respiration Uterus Heart Muscle Smooth Stimulation Chemical Rats Meclofenamic acid Anesthesia Cats Female Rabbits Serotonin Muscle Contraction medicine.drug |
| Zdroj: | Toxicon. 12:75-78 |
| ISSN: | 0041-0101 |
| DOI: | 10.1016/0041-0101(74)90102-0 |
| Popis: | Venom from the scorpion Pandinus exitialis was fractionated on Cellogel membranes into at least 14 bands in acetate buffer pH 4·2, and into 16 bands, 4 of which exhibited cathodic mobility, in barbitone buffer, pH 8·6. The venom was fractionated into 6 fractions using Biogel P 100. The ld 50 of the venom following i.p. injection into mice was estimated to be 40 mg/kg. The cardiovascular effects of the venom appeared to be mediated through stimulation of the autonomic nervous system with a predominance of sympathetic stimulation, and release of tissue catecholamines. On the rat uterus the venom produced a powerful contraction which was greatly attenuated by methysergide and completely blocked by meclofenamic acid indicating that the contraction is mediated partly by the serotonin content of the venom and partly through the release of kinins, prostaglandins and/or slow reacting substance. |
| Databáze: | OpenAIRE |
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