Optic nerve crush modulates refractive development of the C57BL/6 mouse by changing multiple ocular dimensions
| Autor: | Shi-Jun Weng, Xiangtian Zhou, Xiong-Li Yang, Jia Qu, Xue Gong, Hao Wu, Fei Yuan, Xiao-Hua Wu, Kang-Wei Qian, Qiongsi Wang, Yun-Yun Li, Furong Huang, Yuan-Yuan Ma, Yong-Mei Zhong, Ai-Lin Liu |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Refractive error genetic structures Tyrosine 3-Monooxygenase Nerve Crush Dopamine Retina Cornea 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology medicine Myopia Animals Visual Pathways Molecular Biology Chemistry General Neuroscience Dopaminergic C57BL/6 Mouse Retinal Optic Nerve medicine.disease eye diseases Mice Inbred C57BL Experimental animal 030104 developmental biology medicine.anatomical_structure Amacrine Cells Optic nerve 3 4-Dihydroxyphenylacetic Acid sense organs Neurology (clinical) 030217 neurology & neurosurgery Developmental Biology medicine.drug |
| Zdroj: | Brain research. 1726 |
| ISSN: | 1872-6240 |
| Popis: | Higher visual centers could modulate visually-guided ocular growth, in addition to local mechanisms intrinsic to the eye. There is evidence that such central modulations could be species (even subspecies)-dependent. While the mouse has recently become an important experimental animal in myopia studies, it remains unclear whether and how visual centers modulate refractive development in mice, an issue that was examined in the present study. We found that optic nerve crush (ONC), performed at P18, could modify normal refractive development in the C57BL/6 mouse raised in normal visual environment. Unexpectedly, sham surgery caused a steeper cornea, leading to a modest myopic refractive shift, but did not induce significant changes in ocular axis length. ONC caused corneal flattening and re-calibrated the refractive set-point in a bidirectional manner, causing significant myopic (-3 D, 54.5%) or hyperopic (+3 D, 18.2%) shifts in refractive error in most (totally 72.7%) animals, both due to changes in ocular axial length. ONC did not change the density of dopaminergic amacrine cells, but increased retinal levels of dopamine and DOPAC. We conclude that higher visual centers are likely to play a role in fine-tuning of ocular growth, thus modifying refractive development in the C57BL/6 mouse. The changes in refractive error induced by ONC are accounted for by alternations in multiple ocular dimensions, including corneal curvature and axial length. |
| Databáze: | OpenAIRE |
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