Optical molecular imaging for detection of Barrett’s-associated neoplasia
| Autor: | Sharmila Anandasabapathy, Rebecca Richards-Kortum, Nadhi Thekkek |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Diagnostic Imaging
Vascular Alterations Pathology medicine.medical_specialty Esophageal Neoplasms Confocal Contrast Media Adenocarcinoma Barrett Esophagus Endoscopic imaging Optical coherence tomography Medical imaging medicine Humans Topic Highlight medicine.diagnostic_test business.industry Gastroenterology General Medicine medicine.disease Autofluorescence Barrett's esophagus Esophagoscopy sense organs Molecular imaging business Tomography Optical Coherence Biomedical engineering |
| Zdroj: | World Journal of Gastroenterology. 17:53 |
| ISSN: | 1007-9327 |
| Popis: | Recent advancements in the endoscopic imaging of Barrett’s esophagus can be used to probe a wide range of optical properties that are altered with neoplastic progression. This review summarizes relevant changes in optical properties as well as imaging approaches that measures those changes. Wide-field imaging approaches include narrow-band imaging that measures changes in light scattering and absorption, and autofluorescence imaging that measure changes in endogenous fluorophores. High-resolution imaging approaches include optical coherence tomography, endocytoscopy, confocal microendoscopy, and high-resolution microendoscopy. These technologies, some coupled with an appropriate contrast agent, can measure differences in glandular morphology, nuclear morphology, or vascular alterations associated with neoplasia. Advances in targeted contrast agents are further discussed. Studies that have explored these technologies are highlighted; as are the advantages and limitations of each. |
| Databáze: | OpenAIRE |
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