Terminalia pallida fruit ethanolic extract ameliorates lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase in isoproterenol-induced myocardial infarcted rats
| Autor: | Abdul Kareem Mohammed, Talal Abdulaziz Mohaya, Lakshmi Devi Kodidhela, Altaf Mohammad, Althaf Hussain Shaik, Nayab Rasool Shaik, Suliman Y. Al Omar |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Very low-density lipoprotein Antioxidant medicine.medical_treatment Article Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Internal medicine medicine lcsh:QH301-705.5 Lipoprotein lipase biology Cholesterol Paraoxonase Lipid metabolism 030104 developmental biology Endocrinology lcsh:Biology (General) chemistry Biochemistry 030220 oncology & carcinogenesis biology.protein lipids (amino acids peptides and proteins) General Agricultural and Biological Sciences |
| Zdroj: | Saudi Journal of Biological Sciences, Vol 25, Iss 3, Pp 431-436 (2018) |
| ISSN: | 1319-562X |
| DOI: | 10.1016/j.sjbs.2017.11.002 |
| Popis: | The present study aimed to evaluate the effect of Terminalia pallida fruit ethanolic extract (TpFE) on lipids, lipoproteins, lipid metabolism marker enzymes and paraoxonase (PON) in isoproterenol (ISO)-induced myocardial infarcted rats. PON is an excellent serum antioxidant enzyme which involves in the protection of low density lipoprotein cholesterol (LDL-C) from the process of oxidation for the prevention of cardiovascular diseases. ISO caused a significant increase in the concentration of total cholesterol, triglycerides, LDL-C, very low density lipoprotein cholesterol and lipid peroxidation whereas significant decrease in the concentration of high density lipoprotein cholesterol. ISO administration also significantly decreased the activities of lecithin cholesterol acyl transferase, PON and lipoprotein lipase whereas significantly increased the activity of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase. Oral pretreatment of TpFE at doses 100, 300 and 500 mg/kg body weight (bw) and gallic acid (15 mg/kg bw) for 30 days challenged with concurrent injection of ISO (85 mg/kg bw) on 29th and 30th day significantly attenuated these alterations and restored the levels of lipids, lipoproteins and the activities of lipid metabolizing enzymes. Also TpFE significantly elevated the serum antioxidant enzyme PON. This is the first report revealed that pretreatment with TPFE ameliorated lipid metabolic marker enzymes and increased the antioxidant PON in ISO treated male albino Wistar rats. Keywords: Terminalia pallida fruit, Gallic acid, Isoproterenol, Lipid metabolism marker enzymes, Paraoxonase, Myocardial infarction |
| Databáze: | OpenAIRE |
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