Chemotactic and phagocytic responses of human alveolar macrophages to activated complement components
| Autor: | Phillip K. Peterson, H. A. Verbrugh, S W Richards, John R. Hoidal, Robert D. Nelson, D E Hammerschmidt |
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| Jazyk: | angličtina |
| Rok vydání: | 1984 |
| Předmět: |
Phagocytosis
Immunology Complement C5a chemical and pharmacologic phenomena Microbiology Immunoglobulin G Opsonin Proteins Humans Opsonin Complement Activation Complement component 5 biology Chemotaxis Macrophages Smoking Complement C5 Complement C3 respiratory system Complement system Infectious Diseases biology.protein Parasitology Research Article |
| Popis: | Human alveolar macrophages (AMs) migrated toward and aggregated to C5a but not toward C5a-deficient serum. Human AMs from cigarette smokers migrated significantly farther than did AMs from nonsmokers. Human AMs phagocytized Escherichia coli opsonized with activated C3. Immunoglobulin G was not required for phagocytosis. Human AMs demonstrate chemotaxis and aggregation to C5a. Further, human AMs can phagocytize bacteria coated with activated C3. |
| Databáze: | OpenAIRE |
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