Solubility Enhancement of Ebastine by Formulating Microemulsion Using D-Optimal Mixture Design: Optimization and Characterization

Autor:	Apoorva Ratnakar Barve, Gauri Ramchandra Kapileshwari, Cleona Elizabeth Mary DCruz, Lalit Kumar, Prashant Jivaji Bhide, Anand Avinash Mahajan, Asmita Sunil Arondekar, Rupesh Kalidas Shirodkar
Rok vydání:	2022
Předmět:	Surface-Active Agents Piperidines Solubility Drug Discovery Histamine H1 Antagonists Molecular Medicine Polysorbates Emulsions Butyrophenones Oleic Acid
Zdroj:	Assay and drug development technologies. 20(6)
ISSN:	1557-8127
Popis:	Ebastine, a histamine H1 antagonist, nonsedating, belonging to BCS class II is used in the treatment of allergic rhinitis and chronic idiopathic urticaria. The current study was intended in augmenting the aqueous solubility and dissolution rate of ebastine, by formulating a microemulsion system using oleic acid, Transcutol
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a539ab6e40b443216ca31507d30580 https://pubmed.ncbi.nlm.nih.gov/36070596 Zobrazit plný text záznamu