Inflammatory markers in pediatric stroke: an attempt to better understanding the pathophysiology

Autor: Sarah E. Buerki, Maja Steinlin, Alexandre N. Datta, Annette Hackenberg, Denis Grandgirard, Stephen L. Leib, Thomas Schmitt-Mechelke, Florence Martin
Přispěvatelé: University of Zurich, Buerki, Sarah E
Rok vydání: 2016
Předmět:
Male
Neurosurgery
Pilot Projects
610 Medicine & health
Disease
030204 cardiovascular system & hematology
Varicella
Pediatrics
Tissue plasminogen activator
03 medical and health sciences
Child Development
0302 clinical medicine
Risk Factors
otorhinolaryngologic diseases
Vascular Disorders
medicine
Humans
Pediatric stroke
cardiovascular diseases
2735 Pediatrics
Perinatology and Child Health
Child
Stroke
Neonatal stroke
Inflammation
Brain Diseases
biology
business.industry
C-reactive protein
Infant
General Medicine
medicine.disease
Pathophysiology
2728 Neurology (clinical)
Neurology
10036 Medical Clinic
Child
Preschool
Pediatrics
Perinatology and Child Health
Immunology
biology.protein
Biomarker (medicine)
Female
Neurology (clinical)
Nervous System Diseases
CRP
business
Biomarkers
030217 neurology & neurosurgery
medicine.drug
Zdroj: Pediatric Neurology Briefs
ISSN: 1090-3798
Popis: BACKGROUND The mechanisms of childhood and perinatal arterial ischemic stroke (AIS) are poorly understood. Multiple risk factors include cerebral arteriopathy, congenital cardiac disease, infection, sickle cell disease, and maternal-fetal conditions in neonates. For infections and parainfectious conditions being the most important a possible inflammatory pathophysiology has long been suspected. This pilot study aims to detect, whether there are any abnormalities of inflammatory markers associated with childhood and neonatal stroke. METHODS The concentration of 23 different metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMPs), endothelial factors, vascular cell adhesion proteins, and cytokines in plasma were measured in 12 children with AIS, 7 healthy age matched controls and 6 full term neonates with perinatal AIS. RESULTS At the time of the acute event children with AIS had significantly elevated levels of MMP-9, TIMP4, IL-6, IL-8 and CRP compared to controls (p
Databáze: OpenAIRE
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