Inflammatory markers in pediatric stroke: an attempt to better understanding the pathophysiology
Autor: | Sarah E. Buerki, Maja Steinlin, Alexandre N. Datta, Annette Hackenberg, Denis Grandgirard, Stephen L. Leib, Thomas Schmitt-Mechelke, Florence Martin |
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Přispěvatelé: | University of Zurich, Buerki, Sarah E |
Rok vydání: | 2016 |
Předmět: |
Male
Neurosurgery Pilot Projects 610 Medicine & health Disease 030204 cardiovascular system & hematology Varicella Pediatrics Tissue plasminogen activator 03 medical and health sciences Child Development 0302 clinical medicine Risk Factors otorhinolaryngologic diseases Vascular Disorders medicine Humans Pediatric stroke cardiovascular diseases 2735 Pediatrics Perinatology and Child Health Child Stroke Neonatal stroke Inflammation Brain Diseases biology business.industry C-reactive protein Infant General Medicine medicine.disease Pathophysiology 2728 Neurology (clinical) Neurology 10036 Medical Clinic Child Preschool Pediatrics Perinatology and Child Health Immunology biology.protein Biomarker (medicine) Female Neurology (clinical) Nervous System Diseases CRP business Biomarkers 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Pediatric Neurology Briefs |
ISSN: | 1090-3798 |
Popis: | BACKGROUND The mechanisms of childhood and perinatal arterial ischemic stroke (AIS) are poorly understood. Multiple risk factors include cerebral arteriopathy, congenital cardiac disease, infection, sickle cell disease, and maternal-fetal conditions in neonates. For infections and parainfectious conditions being the most important a possible inflammatory pathophysiology has long been suspected. This pilot study aims to detect, whether there are any abnormalities of inflammatory markers associated with childhood and neonatal stroke. METHODS The concentration of 23 different metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMPs), endothelial factors, vascular cell adhesion proteins, and cytokines in plasma were measured in 12 children with AIS, 7 healthy age matched controls and 6 full term neonates with perinatal AIS. RESULTS At the time of the acute event children with AIS had significantly elevated levels of MMP-9, TIMP4, IL-6, IL-8 and CRP compared to controls (p |
Databáze: | OpenAIRE |
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