Bronchial responsiveness to inhaled histamine and exercise
| Autor: | M.T. Cuff, R.C. Anderton, J.L.C. Morse, Norman L. Jones, D.W. Cockcroft, Frederick E. Hargreave, Peter Frith |
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| Rok vydání: | 1979 |
| Předmět: |
Adult
Male Adolescent Immunology Bronchi Treadmill exercise chemistry.chemical_compound Heart Rate Forced Expiratory Volume Humans Immunology and Allergy Medicine Cycle ergometer Treadmill Child Administration Intranasal Asthma business.industry Lability respiratory system medicine.disease respiratory tract diseases chemistry Bronchial hyperresponsiveness Anesthesia Exercise Test Female business Cycle ergometry Histamine |
| Zdroj: | Journal of Allergy and Clinical Immunology. 63:315-320 |
| ISSN: | 0091-6749 |
| Popis: | Bronchial responsiveness to inhaled histamine and exercise was measured in 19 asthmatics. Histamine aerosol was inhaled to determine the provocative concentration producing a 20% fall in forced expired volume in one second (FEV 1 ) (PC 20 ). Exercise was performed on a treadmill and a cycle ergometer; following each procedure the percent fall in the FEV 1 (ΔFEV 1 ) and the exercise lability (percent rise in FEV 1 plus percent fall in FEV 1 ) were calculated. ΔFEV 1 and exercise lability after both forms of exercise were similar. PC 20 correlated with ΔFEV 1 and exercise lability in both forms of exercise; however, the correlation with exercise lability was better. PC 20 was more sensitive in demonstrating bronchial hyperresponsiveness. The close correlation between the level of bronchial responsiveness to histamine and exercise supports the view that release of endogenous chemical mediators is an important determinant of exercise-induced asthma. The treadmill exercise and cycle ergometry protocols were equally effective in producing exercise-induced asthma. |
| Databáze: | OpenAIRE |
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